(E)-3-(6-bromo-7-fluoro-2-(4-methoxybenzylamino)quinolin-3-yl)-N-(cyclohexylmethyl)acrylamide

Base Information

Chemical Name:(E)-3-(6-bromo-7-fluoro-2-(4-methoxybenzylamino)quinolin-3-yl)-N-(cyclohexylmethyl)acrylamide
CAS No.:1309365-73-8
Molecular Formula:C₂₇H₂₉BrFN₃O₂
Molecular Weight:526.449
Hs Code.:

Synonyms:(E)-3-(6-bromo-7-fluoro-2-(4-methoxybenzylamino)quinolin-3-yl)-N-(cyclohexylmethyl)acrylamide

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Chemical Property of (E)-3-(6-bromo-7-fluoro-2-(4-methoxybenzylamino)quinolin-3-yl)-N-(cyclohexylmethyl)acrylamide

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Technology Process of (E)-3-(6-bromo-7-fluoro-2-(4-methoxybenzylamino)quinolin-3-yl)-N-(cyclohexylmethyl)acrylamide

There total 5 articles about (E)-3-(6-bromo-7-fluoro-2-(4-methoxybenzylamino)quinolin-3-yl)-N-(cyclohexylmethyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₁₆BrFN₂O₃

: 3218-02-8
cyclohexylmethylamine

: 1309365-73-8
(E)-3-(6-bromo-7-fluoro-2-(4-methoxybenzylamino)quinolin-3-yl)-N-(cyclohexylmethyl)acrylamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; for 1h;

Reference yield:

: 1309365-71-6
6-bromo-7-fluoro-2-(4-methoxybenzylamino)quinoline-3-carbaldehyde

: 1309365-73-8
(E)-3-(6-bromo-7-fluoro-2-(4-methoxybenzylamino)quinolin-3-yl)-N-(cyclohexylmethyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 2.5 h / 70 °C

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 0.75 h / 20 °C

2.2: pH ~ 1

3.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / 1-methyl-pyrrolidin-2-one / 1 h

With water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol;

Reference yield:

: 351-30-4
N-(4-bromo-3-fluorophenyl)ethanamide

: 1309365-73-8
(E)-3-(6-bromo-7-fluoro-2-(4-methoxybenzylamino)quinolin-3-yl)-N-(cyclohexylmethyl)acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / 48.5 h / 75 °C / Inert atmosphere; Sealed tube; Cooling with ice

2.1: ethanol / 2.5 h / 125 °C / Sealed tube

3.1: tetrahydrofuran / 2.5 h / 70 °C

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 0.75 h / 20 °C

4.2: pH ~ 1

5.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / 1-methyl-pyrrolidin-2-one / 1 h

With water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol;