ethyl [2,6-bis-(3-tert-butoxycarbonylamino-propyl)-4'-pyren-1-yl-biphenyl-4-yl]acetate

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Chemical Name:ethyl [2,6-bis-(3-tert-butoxycarbonylamino-propyl)-4'-pyren-1-yl-biphenyl-4-yl]acetate
CAS No.:386267-39-6
Molecular Formula:C₄₈H₅₄N₂O₆
Molecular Weight:754.967
Hs Code.:

Synonyms:ethyl [2,6-bis-(3-tert-butoxycarbonylamino-propyl)-4'-pyren-1-yl-biphenyl-4-yl]acetate

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Chemical Property of ethyl [2,6-bis-(3-tert-butoxycarbonylamino-propyl)-4'-pyren-1-yl-biphenyl-4-yl]acetate

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Technology Process of ethyl [2,6-bis-(3-tert-butoxycarbonylamino-propyl)-4'-pyren-1-yl-biphenyl-4-yl]acetate

There total 10 articles about ethyl [2,6-bis-(3-tert-butoxycarbonylamino-propyl)-4'-pyren-1-yl-biphenyl-4-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 78888-18-3
N-tert-butoxycarbonylprop-2-en-1-amine

: 386267-37-4
ethyl (2,6-dibromo-4'-pyren-1-yl-biphenyl-4-yl)acetate

: 386267-39-6
ethyl [2,6-bis-(3-tert-butoxycarbonylamino-propyl)-4'-pyren-1-yl-biphenyl-4-yl]acetate

Guidance literature:: N-tert-butoxycarbonylprop-2-en-1-amine; With 9-borabicyclo[3.3.1]nonane dimer; In tetrahydrofuran; for 12h;

ethyl (2,6-dibromo-4'-pyren-1-yl-biphenyl-4-yl)acetate; With potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In xylene; for 48h; Heating;
DOI:10.1055/s-2001-18066

Reference yield:

: 345924-29-0
1-(4-Bromophenyl)pyrene

: 386267-39-6
ethyl [2,6-bis-(3-tert-butoxycarbonylamino-propyl)-4'-pyren-1-yl-biphenyl-4-yl]acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / tetrahydrofuran / 6 h / -78 - 20 °C

1.2: B(O-iPr)3 / tetrahydrofuran / 10 h / -78 - 20 °C

2.1: 17.0 g / acetone / 1 h / Heating

3.1: 44 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / m-xylene / 72 h / Heating

4.1: 9-BBN / tetrahydrofuran / 12 h

4.2: 76 percent / aq. KOH / Pd(PPh₃)4 / xylene / 48 h / Heating

With 9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; m-xylene; acetone; 3.1: Suzuki cross-coupling / 4.2: Suzuki cross-coupling;
DOI:10.1055/s-2001-18066

Reference yield:

: 349666-24-6
1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrene

: 386267-39-6
ethyl [2,6-bis-(3-tert-butoxycarbonylamino-propyl)-4'-pyren-1-yl-biphenyl-4-yl]acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 91 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / toluene / 48 h / Heating

2.1: n-BuLi / tetrahydrofuran / 6 h / -78 - 20 °C

2.2: B(O-iPr)3 / tetrahydrofuran / 10 h / -78 - 20 °C

3.1: 17.0 g / acetone / 1 h / Heating

4.1: 44 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / m-xylene / 72 h / Heating

5.1: 9-BBN / tetrahydrofuran / 12 h

5.2: 76 percent / aq. KOH / Pd(PPh₃)4 / xylene / 48 h / Heating

With 9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; m-xylene; acetone; toluene; 1.1: Suzuki cross-coupling / 4.1: Suzuki cross-coupling / 5.2: Suzuki cross-coupling;
DOI:10.1055/s-2001-18066