[2,6-bis-(3-tert-butoxycarbonylamino-propyl)-4'-pyren-1-yl-biphenyl-4-yl]acetic acid

Base Information

Chemical Name:[2,6-bis-(3-tert-butoxycarbonylamino-propyl)-4'-pyren-1-yl-biphenyl-4-yl]acetic acid
CAS No.:386267-40-9
Molecular Formula:C₄₆H₅₀N₂O₆
Molecular Weight:726.913
Hs Code.:

Synonyms:[2,6-bis-(3-tert-butoxycarbonylamino-propyl)-4'-pyren-1-yl-biphenyl-4-yl]acetic acid

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Chemical Property of [2,6-bis-(3-tert-butoxycarbonylamino-propyl)-4'-pyren-1-yl-biphenyl-4-yl]acetic acid

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Technology Process of [2,6-bis-(3-tert-butoxycarbonylamino-propyl)-4'-pyren-1-yl-biphenyl-4-yl]acetic acid

There total 12 articles about [2,6-bis-(3-tert-butoxycarbonylamino-propyl)-4'-pyren-1-yl-biphenyl-4-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 386267-39-6
ethyl [2,6-bis-(3-tert-butoxycarbonylamino-propyl)-4'-pyren-1-yl-biphenyl-4-yl]acetate

: 386267-40-9
[2,6-bis-(3-tert-butoxycarbonylamino-propyl)-4'-pyren-1-yl-biphenyl-4-yl]acetic acid

Guidance literature:: With potassium hydroxide; In methanol; for 2h; Heating;
DOI:10.1055/s-2001-18066

Reference yield:

: 345924-29-0
1-(4-Bromophenyl)pyrene

: 386267-40-9
[2,6-bis-(3-tert-butoxycarbonylamino-propyl)-4'-pyren-1-yl-biphenyl-4-yl]acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-BuLi / tetrahydrofuran / 6 h / -78 - 20 °C

1.2: B(O-iPr)3 / tetrahydrofuran / 10 h / -78 - 20 °C

2.1: 17.0 g / acetone / 1 h / Heating

3.1: 44 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / m-xylene / 72 h / Heating

4.1: 9-BBN / tetrahydrofuran / 12 h

4.2: 76 percent / aq. KOH / Pd(PPh₃)4 / xylene / 48 h / Heating

5.1: 88 percent / aq. KOH / methanol / 2 h / Heating

With potassium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; m-xylene; acetone; 3.1: Suzuki cross-coupling / 4.2: Suzuki cross-coupling;
DOI:10.1055/s-2001-18066

Reference yield:

: 349666-24-6
1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrene

: 386267-40-9
[2,6-bis-(3-tert-butoxycarbonylamino-propyl)-4'-pyren-1-yl-biphenyl-4-yl]acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: 91 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / toluene / 48 h / Heating

2.1: n-BuLi / tetrahydrofuran / 6 h / -78 - 20 °C

2.2: B(O-iPr)3 / tetrahydrofuran / 10 h / -78 - 20 °C

3.1: 17.0 g / acetone / 1 h / Heating

4.1: 44 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / m-xylene / 72 h / Heating

5.1: 9-BBN / tetrahydrofuran / 12 h

5.2: 76 percent / aq. KOH / Pd(PPh₃)4 / xylene / 48 h / Heating

6.1: 88 percent / aq. KOH / methanol / 2 h / Heating

With potassium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; m-xylene; acetone; toluene; 1.1: Suzuki cross-coupling / 4.1: Suzuki cross-coupling / 5.2: Suzuki cross-coupling;
DOI:10.1055/s-2001-18066