2,2,2-trifluoro-1-hydroxy-1-{[(4-nitrophenyl)sulfanyl]methyl}ethyl cyanide

Base Information

Chemical Name:2,2,2-trifluoro-1-hydroxy-1-{[(4-nitrophenyl)sulfanyl]methyl}ethyl cyanide
CAS No.:476314-47-3
Molecular Formula:C₁₀H₇F₃N₂O₃S
Molecular Weight:292.238
Hs Code.:

Synonyms:2,2,2-trifluoro-1-hydroxy-1-{[(4-nitrophenyl)sulfanyl]methyl}ethyl cyanide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,2,2-trifluoro-1-hydroxy-1-{[(4-nitrophenyl)sulfanyl]methyl}ethyl cyanide

Chemical Property:

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Technology Process of 2,2,2-trifluoro-1-hydroxy-1-{[(4-nitrophenyl)sulfanyl]methyl}ethyl cyanide

There total 3 articles about 2,2,2-trifluoro-1-hydroxy-1-{[(4-nitrophenyl)sulfanyl]methyl}ethyl cyanide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 151-50-8
potassium cyanide

: 90357-44-1
1,1,1-trifluoro-3-[(4-nitrophenyl)sulfanyl]acetone

: 476314-47-3
2,2,2-trifluoro-1-hydroxy-1-{[(4-nitrophenyl)sulfanyl]methyl}ethyl cyanide

Guidance literature:: With sulfuric acid; In water; at 0 - 25 ℃; for 20h;
DOI:10.1016/S0223-5234(02)01335-1

Reference yield:

: 13113-79-6
sodium 4-nitrobenzenethiolate

: 476314-47-3
2,2,2-trifluoro-1-hydroxy-1-{[(4-nitrophenyl)sulfanyl]methyl}ethyl cyanide

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent / tetrahydrofuran / 3 h / 0 - 25 °C

2: 67 percent / H₂SO₄ / H₂O / 20 h / 0 - 25 °C

With sulfuric acid; In tetrahydrofuran; water;
DOI:10.1016/S0223-5234(02)01335-1