2-bromo-7-chloro-9H-fluorene

Base Information

• Chemical Name: 2-bromo-7-chloro-9H-fluorene
• CAS No.: 99586-26-2
• Molecular Formula: C₁₃H₈BrCl
• Molecular Weight: 279.564
• Mol file: 99586-26-2.mol

Synonyms:2-bromo-7-chloro-9H-fluorene

Chemical Property of 2-bromo-7-chloro-9H-fluorene

Chemical Property:

• Melting Point: 156-157 °C
• Boiling Point: 386.8±35.0 °C(Predicted)
• Density: 1.584±0.06 g/cm3(Predicted)

Purity/Quality:

98%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-bromo-7-chloro-9H-fluorene

There total 1 articles about 2-bromo-7-chloro-9H-fluorene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-7-bromofluorene (6638-60-4) → 2-bromo-7-chloro-9H-fluorene (99586-26-2)

Guidance literature:

With hydrogenchloride; Diazotization_.Behandlung der Diazoniumsalz-Loesung mit Kupfer-Pulver;

Reference yield:

2-bromo-7-chloro-9H-fluorene (99586-26-2) → methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate (1256388-51-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium hexamethylsilazane; N-fluorobis(benzenesulfon)imide / di-isopropyl ether / 2.5 h / -65 °C / Inert atmosphere

2.1: potassium carbonate; palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / N,N-dimethyl acetamide / 5 h / 120 °C / Inert atmosphere

3.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydrogencarbonate / 1,2-dimethoxyethane / 6 h / 110 °C / Inert atmosphere

4.1: hydrogen bromide / acetone / 6 h / 75 °C

5.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 0.5 h / 20 °C

5.2: 3 h / 0 - 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; hydrogen bromide; palladium diacetate; potassium hexamethylsilazane; sodium hydrogencarbonate; potassium carbonate; N-fluorobis(benzenesulfon)imide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,2-dimethoxyethane; dichloromethane; di-isopropyl ether; N,N-dimethyl acetamide; acetone; 3.1: |Suzuki Coupling;

Reference yield:

2-bromo-7-chloro-9H-fluorene (99586-26-2) + methyl iodide (74-88-4) → 2-bromo-7-chloro-9,9-dimethyl-9H-fluorene (605630-37-3)

Guidance literature:

With sodium hydroxide;

upstream raw materials:

2-amino-7-bromofluorene

Downstream raw materials:

2-bromo-7-chloro-9,9-dimethyl-9H-fluorene

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate