ethyl [6-(hydroxymethyl)-4-[2-(4-(2-[2-(2-methoxyethoxy)ethoxy]ethoxy)phenyl)ethynyl]pyridin-2-yl](phenyl)phosphinate

Base Information

Chemical Name:ethyl [6-(hydroxymethyl)-4-[2-(4-(2-[2-(2-methoxyethoxy)ethoxy]ethoxy)phenyl)ethynyl]pyridin-2-yl](phenyl)phosphinate
CAS No.:1417729-09-9
Molecular Formula:C₂₉H₃₄NO₇P
Molecular Weight:539.565
Hs Code.:

Synonyms:ethyl [6-(hydroxymethyl)-4-[2-(4-(2-[2-(2-methoxyethoxy)ethoxy]ethoxy)phenyl)ethynyl]pyridin-2-yl](phenyl)phosphinate

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Chemical Property of ethyl [6-(hydroxymethyl)-4-[2-(4-(2-[2-(2-methoxyethoxy)ethoxy]ethoxy)phenyl)ethynyl]pyridin-2-yl](phenyl)phosphinate

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Technology Process of ethyl [6-(hydroxymethyl)-4-[2-(4-(2-[2-(2-methoxyethoxy)ethoxy]ethoxy)phenyl)ethynyl]pyridin-2-yl](phenyl)phosphinate

There total 14 articles about ethyl [6-(hydroxymethyl)-4-[2-(4-(2-[2-(2-methoxyethoxy)ethoxy]ethoxy)phenyl)ethynyl]pyridin-2-yl](phenyl)phosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1417729-01-1
(6-[ethoxy(phenyl)phosphoryl]-4-[2-(4-(2-[2-(2-methoxyethoxy)ethoxy]ethoxy)phenyl)ethynyl]pyridin-2-yl)methyl acetate

: 1417729-09-9
ethyl [6-(hydroxymethyl)-4-[2-(4-(2-[2-(2-methoxyethoxy)ethoxy]ethoxy)phenyl)ethynyl]pyridin-2-yl](phenyl)phosphinate

Guidance literature:: With ethanol; sodium; at 50 ℃; Inert atmosphere;
DOI:10.1039/c2cc35247h

Reference yield:

: 91668-84-7
2-bromo-6-methylpyridine N-oxide

: 1417729-09-9
ethyl [6-(hydroxymethyl)-4-[2-(4-(2-[2-(2-methoxyethoxy)ethoxy]ethoxy)phenyl)ethynyl]pyridin-2-yl](phenyl)phosphinate

Guidance literature:: Multi-step reaction with 9 steps

1.1: nitric acid; sulfuric acid / 16 h / 0 - 100 °C

2.1: phosphorus tribromide / chloroform / 16 h / 60 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / toluene / 16 h / 125 °C / Inert atmosphere

4.1: Acetyl bromide / 16 h / 70 °C / Inert atmosphere

4.2: 0 °C

5.1: 72 h / 140 °C / Inert atmosphere

6.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 16 h / 65 °C / Inert atmosphere

7.1: 3 h / 120 °C

8.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; copper(l) iodide; tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 65 °C / Inert atmosphere

9.1: ethanol; sodium / 50 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Acetyl bromide; ethanol; sulfuric acid; tetrabutyl ammonium fluoride; nitric acid; sodium; phosphorus tribromide; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; chloroform; toluene;
DOI:10.1039/c2cc35247h

Reference yield:

: 97944-46-2
2-bromo-6-methyl-4-nitro-pyridine

: 1417729-09-9
ethyl [6-(hydroxymethyl)-4-[2-(4-(2-[2-(2-methoxyethoxy)ethoxy]ethoxy)phenyl)ethynyl]pyridin-2-yl](phenyl)phosphinate

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / toluene / 16 h / 125 °C / Inert atmosphere

2.1: Acetyl bromide / 16 h / 70 °C / Inert atmosphere

2.2: 0 °C

3.1: 72 h / 140 °C / Inert atmosphere

4.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 16 h / 65 °C / Inert atmosphere

5.1: 3 h / 120 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; copper(l) iodide; tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 65 °C / Inert atmosphere

7.1: ethanol; sodium / 50 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Acetyl bromide; ethanol; tetrabutyl ammonium fluoride; sodium; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; chloroform; toluene;
DOI:10.1039/c2cc35247h