(6-[ethoxy(phenyl)phosphoryl]-4-[2-(4-(2-[2-(2-methoxyethoxy)ethoxy]ethoxy)phenyl)ethynyl]pyridin-2-yl)methyl acetate

Base Information

Chemical Name:(6-[ethoxy(phenyl)phosphoryl]-4-[2-(4-(2-[2-(2-methoxyethoxy)ethoxy]ethoxy)phenyl)ethynyl]pyridin-2-yl)methyl acetate
CAS No.:1417729-01-1
Molecular Formula:C₃₁H₃₆NO₈P
Molecular Weight:581.602
Hs Code.:

Synonyms:(6-[ethoxy(phenyl)phosphoryl]-4-[2-(4-(2-[2-(2-methoxyethoxy)ethoxy]ethoxy)phenyl)ethynyl]pyridin-2-yl)methyl acetate

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Chemical Property of (6-[ethoxy(phenyl)phosphoryl]-4-[2-(4-(2-[2-(2-methoxyethoxy)ethoxy]ethoxy)phenyl)ethynyl]pyridin-2-yl)methyl acetate

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Technology Process of (6-[ethoxy(phenyl)phosphoryl]-4-[2-(4-(2-[2-(2-methoxyethoxy)ethoxy]ethoxy)phenyl)ethynyl]pyridin-2-yl)methyl acetate

There total 12 articles about (6-[ethoxy(phenyl)phosphoryl]-4-[2-(4-(2-[2-(2-methoxyethoxy)ethoxy]ethoxy)phenyl)ethynyl]pyridin-2-yl)methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1078714-74-5
[2-(4-(2-[2-(2-methoxyethoxy)ethoxy]ethoxy)phenyl)ethynyl]trimethylsilane

: 1417729-00-0
(4-bromo-6-[ethoxy(phenyl)phosphoryl]pyridine-2-yl)methyl acetate

: 1417729-01-1
(6-[ethoxy(phenyl)phosphoryl]-4-[2-(4-(2-[2-(2-methoxyethoxy)ethoxy]ethoxy)phenyl)ethynyl]pyridin-2-yl)methyl acetate

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; at 65 ℃; for 3h; Inert atmosphere;
DOI:10.1039/c2cc35247h

Reference yield:

: 91668-84-7
2-bromo-6-methylpyridine N-oxide

: 1417729-01-1
(6-[ethoxy(phenyl)phosphoryl]-4-[2-(4-(2-[2-(2-methoxyethoxy)ethoxy]ethoxy)phenyl)ethynyl]pyridin-2-yl)methyl acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: nitric acid; sulfuric acid / 16 h / 0 - 100 °C

2.1: phosphorus tribromide / chloroform / 16 h / 60 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / toluene / 16 h / 125 °C / Inert atmosphere

4.1: Acetyl bromide / 16 h / 70 °C / Inert atmosphere

4.2: 0 °C

5.1: 72 h / 140 °C / Inert atmosphere

6.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 16 h / 65 °C / Inert atmosphere

7.1: 3 h / 120 °C

8.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; copper(l) iodide; tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 65 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Acetyl bromide; sulfuric acid; tetrabutyl ammonium fluoride; nitric acid; phosphorus tribromide; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; chloroform; toluene;
DOI:10.1039/c2cc35247h

Reference yield:

: 97944-46-2
2-bromo-6-methyl-4-nitro-pyridine

: 1417729-01-1
(6-[ethoxy(phenyl)phosphoryl]-4-[2-(4-(2-[2-(2-methoxyethoxy)ethoxy]ethoxy)phenyl)ethynyl]pyridin-2-yl)methyl acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / toluene / 16 h / 125 °C / Inert atmosphere

2.1: Acetyl bromide / 16 h / 70 °C / Inert atmosphere

2.2: 0 °C

3.1: 72 h / 140 °C / Inert atmosphere

4.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 16 h / 65 °C / Inert atmosphere

5.1: 3 h / 120 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; copper(l) iodide; tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 65 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Acetyl bromide; tetrabutyl ammonium fluoride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; chloroform; toluene;
DOI:10.1039/c2cc35247h