N-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}phenyl)glycine methyl ester

Base Information

Chemical Name:N-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}phenyl)glycine methyl ester
CAS No.:943345-12-8
Molecular Formula:C₂₈H₂₃N₃O₅
Molecular Weight:481.508
Hs Code.:

Synonyms:N-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}phenyl)glycine methyl ester

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Chemical Property of N-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}phenyl)glycine methyl ester

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Technology Process of N-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}phenyl)glycine methyl ester

There total 5 articles about N-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}phenyl)glycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.8%

: 943344-65-8
3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}aniline

: 96-32-2
bromoacetic acid methyl ester

: 943345-12-8
N-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}phenyl)glycine methyl ester

Guidance literature:: With caesium carbonate; In acetone; Reflux;

Reference yield:

: 4254-17-5
4-methoxybenzoin

: 943345-12-8
N-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}phenyl)glycine methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethylamine / N,N-dimethyl-formamide / 5 h / 20 °C / Cooling with ice

2.1: acetic anhydride / 0 °C

2.2: 10 - 130 °C

3.1: trichlorophosphate / 1 h / Reflux

3.2: 55 - 75 °C / pH 9

4.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C

5.1: caesium carbonate / acetone / Reflux

With acetic anhydride; potassium carbonate; caesium carbonate; diethylamine; trichlorophosphate; In N,N-dimethyl-formamide; acetone;

Reference yield:

: 943230-30-6
5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4(3H)-one

: 943345-12-8
N-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}phenyl)glycine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 1 h / Reflux

1.2: 55 - 75 °C / pH 9

2.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C

3.1: caesium carbonate / acetone / Reflux

With potassium carbonate; caesium carbonate; trichlorophosphate; In N,N-dimethyl-formamide; acetone;