N-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}phenyl)glycine

Base Information

Chemical Name:N-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}phenyl)glycine
CAS No.:943345-13-9
Molecular Formula:C₂₇H₂₁N₃O₅
Molecular Weight:467.481
Hs Code.:

Synonyms:N-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}phenyl)glycine

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Chemical Property of N-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}phenyl)glycine

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Technology Process of N-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}phenyl)glycine

There total 6 articles about N-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}phenyl)glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.8%

: 943345-12-8
N-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}phenyl)glycine methyl ester

: 943345-13-9
N-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}phenyl)glycine

Guidance literature:: N-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}phenyl)glycine methyl ester; With water; sodium hydroxide; In 1,4-dioxane; at 20 ℃;

With hydrogenchloride; In 1,4-dioxane; water;

Reference yield:

: 4254-17-5
4-methoxybenzoin

: 943345-13-9
N-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}phenyl)glycine

Guidance literature:: Multi-step reaction with 6 steps

1.1: diethylamine / N,N-dimethyl-formamide / 5 h / 20 °C / Cooling with ice

2.1: acetic anhydride / 0 °C

2.2: 10 - 130 °C

3.1: trichlorophosphate / 1 h / Reflux

3.2: 55 - 75 °C / pH 9

4.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C

5.1: caesium carbonate / acetone / Reflux

6.1: sodium hydroxide; water / 1,4-dioxane / 20 °C

With water; acetic anhydride; potassium carbonate; caesium carbonate; diethylamine; sodium hydroxide; trichlorophosphate; In 1,4-dioxane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 943230-30-6
5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4(3H)-one

: 943345-13-9
N-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}phenyl)glycine

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / 1 h / Reflux

1.2: 55 - 75 °C / pH 9

2.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C

3.1: caesium carbonate / acetone / Reflux

4.1: sodium hydroxide; water / 1,4-dioxane / 20 °C

With water; potassium carbonate; caesium carbonate; sodium hydroxide; trichlorophosphate; In 1,4-dioxane; N,N-dimethyl-formamide; acetone;