4-chloro-2-[4-(4-fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-2-ylsulfanylmethyl]-6-methylsulfanyl-phenol

Base Information

• Chemical Name: 4-chloro-2-[4-(4-fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-2-ylsulfanylmethyl]-6-methylsulfanyl-phenol
• CAS No.: 262589-73-1
• Molecular Formula: C₂₂H₁₇ClFN₃OS₂
• Molecular Weight: 457.98

Synonyms:4-chloro-2-[4-(4-fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-2-ylsulfanylmethyl]-6-methylsulfanyl-phenol

Chemical Property of 4-chloro-2-[4-(4-fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-2-ylsulfanylmethyl]-6-methylsulfanyl-phenol

Chemical Property:

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Technology Process of 4-chloro-2-[4-(4-fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-2-ylsulfanylmethyl]-6-methylsulfanyl-phenol

There total 2 articles about 4-chloro-2-[4-(4-fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-2-ylsulfanylmethyl]-6-methylsulfanyl-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

4-(4-fluorophenyl)-5-(pyridin-4-yl)-1,3-dihydro-imidazole-2-thione (72882-75-8) + 4-chloro-2-hydroxymethyl-6-methylsulfanylphenol (262589-84-4) → 4-chloro-2-[4-(4-fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-2-ylsulfanylmethyl]-6-methylsulfanyl-phenol (262589-73-1)

Guidance literature:

With acetic acid; at 75 ℃; for 1.5h;

DOI:10.1021/jm020873z

Reference yield:

5-chloro-2-hydroxy-3-methylsulfanylbenzoic acid (68029-68-5) → 4-chloro-2-[4-(4-fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-2-ylsulfanylmethyl]-6-methylsulfanyl-phenol (262589-73-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / LiAlH₄ / tetrahydrofuran / 60 °C

2: 62 percent / 10percent HCl; AcOH / 1.5 h / 75 °C

With lithium aluminium tetrahydride; acetic acid; In tetrahydrofuran;

DOI:10.1021/jm020873z

Reference yield:

4-chloro-2-[4-(4-fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-2-ylsulfanylmethyl]-6-methylsulfanyl-phenol (262589-73-1) → 4-chloro-2-[4-(4-fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-2-ylsulfanylmethyl]-6-methanesulfinyl-phenol

Guidance literature:

With acetic acid; at 20 ℃; for 4h;

DOI:10.1021/jm020873z

upstream raw materials:

4-(4-fluorophenyl)-5-(pyridin-4-yl)-1,3-dihydro-imidazole-2-thione

4-chloro-2-hydroxymethyl-6-methylsulfanylphenol

5-chloro-2-hydroxy-3-methylsulfanylbenzoic acid

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