72882-75-8

Upstream product

• 333-20-0 potassium thioacyanate 
• 87532-41-0 1-(4-Fluoro-phenyl)-2-hydroxy-2-pyridin-4-yl-ethanone 
• 17356-08-0 thiourea 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 459-22-3 4-fluorophenylacetonitrile 
• 115858-98-5 1-(4-fluorophenyl)-2-(pyridin-4-yl)-2-ethanone 
• 115859-01-3 1-(4-pyridyl)-2-(4-fluorophenyl)ethanone oxime 
• 115858-97-4 1-(4-pyridyl)-2-cyano-2-(4-fluorophenyl)ethanone 
• 115859-00-2 1-(4-pyridyl)-1-ethoxy-2-(4-fluorophenyl)aziridine 
• 115858-99-6 1-(4-pyridyl)-2-(4-fluorophenyl)-1-<(tolylsulfonyl)imino>ethane 

Downstream Products

• 72873-74-6 5-(4-pyridyl)-6-(4-fluorophenyl)-2,3-dihydroimidazo[2,1-b]thiazole 
• 72873-75-7 5-(4-Fluorophenyl)-6-(4'-pyridyl)-2,3-dihydroimidazo[2,1-b]thiazole 
• 475585-80-9 2-[5-(4-fluorophenyl)-4-pyridin-4-yl-1H-imidazol-2-ylsulfanylmethyl]-phenol 
• 110764-04-0 2,2'-[1,3-propan-2-onediylbis(thio)]bis[4-(4-fluoro-phenyl)-5-(4-pyridyl)-1H-imidazole] 
• 627080-51-7 3-(4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-ylthio)propane-1,2-diol 
• 627080-56-2 methyl 4-(4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-ylthio)butanoate 
• 627080-58-4 methyl 2-(4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-ylthio)acetate 
• 627080-52-8 diethyl 2-(4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-ylthio)malonate 
• 1061601-11-3 2-(4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-ylthio)ethanol 

Relevant academic research and scientific papers

Targeting the ribose and phosphate binding site of p38 mitogen-activated protein (MAP) kinase: Synthesis and biological testing of 2-alkylsulfanyl-, 4(5)-aryl-, 5(4)-heteroaryl-substituted imidazoles

Three series of substituted 2-alkylsulfanyl-4-(4-fluorophenyl)imidazoles, 5-pyridinyl-, 1-methyl-5-pyridinyl-, and 5-(2-aminopyridin-4-yl)-imidazoles, were prepared and tested for their ability to inhibit p38 MAP kinase and TNF-α release. These compounds

2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE IN PHARMACEUTICS

The invention relates to 2-thio-substituted imidazole derivatives of formula (I), wherein the radicals R1, R2, R3 and m have the meanings as cited in the description. The inventive compounds comprise an immunomodulatory action and/or an action that inhibits the release of cytokines and are thus suited for treating diseases associated with a disorder of the immune system.

Synthetic and Mechanistic Studies on the Preparation of Pyridyl-Substituted Imidazothiazoles

A new method is presented for the introduction of the 4'-pyridyl substituent into 6-aryl-2,3-dihydroimidazothiazoles.The method involves treatment of the imidazothiazolines with the reactive complex of pyridine and ethyl chloroformate and oxidative deethyl carboxylation of the dihydropyridine adducts formed.Sulfur in refluxing mesitylene was found most suitable for the latter reaction, but chromium trioxide in pyridine or KtBuO and air were also effective.

Antiinflammatory Activity of 5,6-Diaryl-2,3-dihydroimidazothiazoles. Isomeric 4-Pyridyl and 4-Substituted Phenyl Derivatives

Isomeric 5(6)-(4-pyridyl)- and 6(5)-(4-substituted-phenyl)-2,3-dihydroimidazo(2,1-b>thiazoles were prepared by a mixed benzoin-imidazothione route, and their structures were assigned by spectral comparison to compounds of established substitution pattern.