(E)-3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]-N-hydroxyacrylamide hydrochloride

Base Information

Chemical Name:(E)-3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]-N-hydroxyacrylamide hydrochloride
CAS No.:1152131-98-0
Molecular Formula:C₃₀H₂₂ClFN₄O₃*ClH
Molecular Weight:577.442
Hs Code.:

Synonyms:(E)-3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]-N-hydroxyacrylamide hydrochloride

Suppliers and Price of (E)-3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]-N-hydroxyacrylamide hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]-N-hydroxyacrylamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]-N-hydroxyacrylamide hydrochloride

There total 3 articles about (E)-3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]-N-hydroxyacrylamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1152131-86-6
(E)-3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide

: 1152131-98-0
(E)-3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]-N-hydroxyacrylamide hydrochloride

Guidance literature:: With hydrogenchloride; water; In methanol; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1021/jm100665z

Reference yield: 85.0%

: 1152131-98-0
(E)-3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]-N-hydroxyacrylamide hydrochloride

Guidance literature:

Reference yield:

: 1152131-78-6
3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]acrylic acid tert-butyl ester

: 1152131-98-0
(E)-3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]-N-hydroxyacrylamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: 0.5 h / 20 °C / Inert atmosphere

1.2: pH 7 / Inert atmosphere

2.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

3.1: hydrogenchloride; water / methanol / 48 h / 20 °C / Inert atmosphere

With hydrogenchloride; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm100665z