(E)-3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide

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Chemical Name:(E)-3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide
CAS No.:1152131-86-6
Molecular Formula:C₃₅H₃₀ClFN₄O₄
Molecular Weight:625.099
Hs Code.:

Synonyms:(E)-3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide

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Chemical Property of (E)-3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide

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Technology Process of (E)-3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide

There total 3 articles about (E)-3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 6723-30-4
O-2-tetrahydro-2H-pyranhydroxylamine

: 3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]acrylic acid trifluoroacetate

: 1152131-86-6
(E)-3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jm100665z

Reference yield: 62.0%

: 1152131-86-6
(E)-3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide

Guidance literature:

Reference yield:

: 1152131-78-6
3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]acrylic acid tert-butyl ester

: 1152131-86-6
(E)-3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 0.5 h / 20 °C / Inert atmosphere

1.2: pH 7 / Inert atmosphere

2.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm100665z