3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]acrylic acid tert-butyl ester

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Chemical Name:3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]acrylic acid tert-butyl ester
CAS No.:1152131-78-6
Molecular Formula:C₃₄H₂₉ClFN₃O₃
Molecular Weight:582.074
Hs Code.:

Synonyms:3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]acrylic acid tert-butyl ester

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Chemical Property of 3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]acrylic acid tert-butyl ester

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Technology Process of 3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]acrylic acid tert-butyl ester

There total 10 articles about 3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]acrylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1152131-72-0
4-{4-[3-chloro-4-(3-fluorobenzyloxy)phenylamino]quinazolin-6-yl}benzaldehyde

: 35000-37-4
(tert-butyloxycarbonylmethyl)triphenylphosphonium chloride

: 1152131-78-6
3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]acrylic acid tert-butyl ester

Guidance literature:: With triethylamine; sodium hydroxide; In dichloromethane; water; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm100665z

Reference yield: 71.0%

: 1152131-78-6
3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]acrylic acid tert-butyl ester

Guidance literature:

Reference yield:

: 98556-31-1
4-chloro-6-iodoquinazoline

: 1152131-78-6
3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]acrylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1 h / Heating; Inert atmosphere

2: bis(triphenylphosphine)palladium(II) dichloride; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 60 °C / Inert atmosphere

3: triethylamine; sodium hydroxide / dichloromethane; water / 20 °C / Inert atmosphere

With bis(triphenylphosphine)palladium(II) dichloride; sodium carbonate; triethylamine; sodium hydroxide; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; 2: Suzuki coupling / 3: Wittig reaction;
DOI:10.1021/jm100665z