2-(4-{4-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-5-methoxy-2-nitrophenyl}piperazin-1-yl)-N,N-dimethylacetamide

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Chemical Name:2-(4-{4-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-5-methoxy-2-nitrophenyl}piperazin-1-yl)-N,N-dimethylacetamide
CAS No.:1421372-24-8
Molecular Formula:C₂₆H₂₈ClN₉O₄
Molecular Weight:566.019
Hs Code.:

Synonyms:2-(4-{4-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-5-methoxy-2-nitrophenyl}piperazin-1-yl)-N,N-dimethylacetamide

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Chemical Property of 2-(4-{4-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-5-methoxy-2-nitrophenyl}piperazin-1-yl)-N,N-dimethylacetamide

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Technology Process of 2-(4-{4-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-5-methoxy-2-nitrophenyl}piperazin-1-yl)-N,N-dimethylacetamide

There total 4 articles about 2-(4-{4-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-5-methoxy-2-nitrophenyl}piperazin-1-yl)-N,N-dimethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1224709-13-0
3-(2,5-dichloropyrimidin-4-yl)pyrazolo[1,5-a]pyridine

: 1421372-24-8
2-(4-{4-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-5-methoxy-2-nitrophenyl}piperazin-1-yl)-N,N-dimethylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / 18 h / 125 °C

2: N-ethyl-N,N-diisopropylamine / 2,2,2-trifluoroethanol / 1 h / 140 °C / Microwave irradiation

With toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In 2,2,2-trifluoroethanol;

Reference yield:

: 1224708-12-6
4-[(E)-2-butoxyethenyl]-2,5-dichloropyrimidine

: 1421372-24-8
2-(4-{4-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-5-methoxy-2-nitrophenyl}piperazin-1-yl)-N,N-dimethylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide; potassium carbonate / dimethyl sulfoxide / 5.5 h / 20 - 90 °C

2: toluene-4-sulfonic acid / 18 h / 125 °C

3: N-ethyl-N,N-diisopropylamine / 2,2,2-trifluoroethanol / 1 h / 140 °C / Microwave irradiation

With potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In 2,2,2-trifluoroethanol; dimethyl sulfoxide;

Reference yield:

: 1075705-01-9
4-fluoro-2-methoxy-5-nitro-phenylamine

: 1421372-24-8
2-(4-{4-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-5-methoxy-2-nitrophenyl}piperazin-1-yl)-N,N-dimethylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / 18 h / 125 °C

2: N-ethyl-N,N-diisopropylamine / 2,2,2-trifluoroethanol / 1 h / 140 °C / Microwave irradiation

With toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In 2,2,2-trifluoroethanol;