2-(4-bromophenyl)-N-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]acetamide

Base Information

Chemical Name:2-(4-bromophenyl)-N-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]acetamide
CAS No.:1353754-84-3
Molecular Formula:C₁₄H₁₃BrN₄O₄
Molecular Weight:381.186
Hs Code.:

Synonyms:2-(4-bromophenyl)-N-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]acetamide

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Chemical Property of 2-(4-bromophenyl)-N-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]acetamide

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Technology Process of 2-(4-bromophenyl)-N-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]acetamide

There total 1 articles about 2-(4-bromophenyl)-N-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 37859-24-8
2-(4-bromophenyl)acetyl chloride

: 187235-71-8
(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-amine hydrochloride

: 1353754-84-3
2-(4-bromophenyl)-N-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1021/jm2012276

Reference yield: 73.0%

: 1353754-84-3
2-(4-bromophenyl)-N-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]acetamide

: 139301-27-2
4-trifluoromethoxyphenylboronic acid

: 1353754-09-2
C₂₁H₁₇F₃N₄O₅

Guidance literature:: 2-(4-bromophenyl)-N-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]acetamide; 4-trifluoromethoxyphenylboronic acid; With potassium carbonate; In ethanol; toluene; for 0.0833333h; Inert atmosphere;

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; toluene; for 1h; Inert atmosphere; Reflux;
DOI:10.1021/jm2012276

Reference yield: 73.0%

: 868662-36-6
6-(trifluoromethyl)-3-pyridinylboronic acid

: 1353754-84-3
2-(4-bromophenyl)-N-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]acetamide

: 1353754-11-6
N-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]-2-{4-[6-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide

Guidance literature:: 6-(trifluoromethyl)-3-pyridinylboronic acid; 2-(4-bromophenyl)-N-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]acetamide; With potassium carbonate; In ethanol; toluene; for 0.0833333h; Inert atmosphere;

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; toluene; for 1h; Inert atmosphere; Reflux;
DOI:10.1021/jm2012276