2-Fluorocyclopentanone

Base Information

Chemical Name:2-Fluorocyclopentanone
CAS No.:1755-12-0
Molecular Formula:C₅H₇FO
Molecular Weight:102.108
Hs Code.:
DSSTox Substance ID:DTXSID201314410
Nikkaji Number:J733.545H

Synonyms:2-fluorocyclopentanone;2-fluorocyclopentan-1-one;1755-12-0;SCHEMBL11406149;DTXSID201314410;MFCD22491237;SY200677;EN300-208006

Suppliers and Price of 2-Fluorocyclopentanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 2-Fluorocyclopentanone

Chemical Property:

XLogP3:0.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:102.048093005
Heavy Atom Count:7
Complexity:90.1

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC(C(=O)C1)F

Technology Process of 2-Fluorocyclopentanone

There total 1 articles about 2-Fluorocyclopentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 19980-43-9
1-(trimethylsilyloxy)cyclopentene

: 420-56-4
trimethylsilyl fluoride

: 1755-12-0
2-fluorocyclopentanone

Guidance literature:: With fluorine; In various solvent(s); at -78 ℃; for 3.5h;
DOI:10.1016/S0040-4039(00)84624-9

Reference yield: 65.0%

: 1755-12-0
2-fluorocyclopentanone

: trans-2-fluorocyclopentan-1-ol

: cis-2-fluorocyclopentan-1-ol

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; Overall yield = 70 %;
DOI:10.1016/j.tetasy.2012.11.011

Reference yield:

: 1755-12-0
2-fluorocyclopentanone

: 1993-91-5,13378-44-4,20421-49-2
(1R,2R)-2-fluorocyclopentan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate; methanol / 0 °C / Inert atmosphere

2: burkholderia cepacia lipase immobilized on diatomite / tert-butyl methyl ether / 20 °C / Inert atmosphere; Enzymatic reaction

3: Novozyme 435 lipase / tert-butyl methyl ether; aq. phosphate buffer / 20 °C / pH 7.2 / Inert atmosphere; Enzymatic reaction

With methanol; sodium tetrahydroborate; Novozyme 435 lipase; burkholderia cepacia lipase immobilized on diatomite; In aq. phosphate buffer; tert-butyl methyl ether;
DOI:10.24820/ARK.5550190.P011.634