1-(3-amino-4,6-difluorophenyl)-6,7-difluoro-8-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Base Information

Chemical Name:1-(3-amino-4,6-difluorophenyl)-6,7-difluoro-8-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
CAS No.:179741-37-8
Molecular Formula:C₁₇H₁₀F₄N₂O₃
Molecular Weight:366.272
Hs Code.:

Synonyms:1-(3-amino-4,6-difluorophenyl)-6,7-difluoro-8-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

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Chemical Property of 1-(3-amino-4,6-difluorophenyl)-6,7-difluoro-8-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

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Technology Process of 1-(3-amino-4,6-difluorophenyl)-6,7-difluoro-8-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

There total 10 articles about 1-(3-amino-4,6-difluorophenyl)-6,7-difluoro-8-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 198013-94-4
ethyl 1-(5-tert-butoxycarbonylamino-2,4-difluorophenyl)-6,7-difluoro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate

: 179741-37-8
1-(3-amino-4,6-difluorophenyl)-6,7-difluoro-8-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Guidance literature:: With hydrogenchloride; acetic acid; Heating;
DOI:10.1021/jm0205090

Reference yield:

: 153775-33-8
2,4-difluoro-5-nitro-benzoic acid

: 179741-37-8
1-(3-amino-4,6-difluorophenyl)-6,7-difluoro-8-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 18 h / 20 °C

2: sodium azide / CH₂Cl₂; dimethylformamide / 0.33 h / 20 °C

3: 149 g / CH₂Cl₂; dimethylformamide / 2 h / Heating

4: 75 percent / H₂ / palladium black / methanol / 72 h / 20 °C

5: CH₂Cl₂ / 20 °C

6: K₂CO₃ / dimethylformamide / 80 °C

7: 96 percent / AcOH; aq. HCl / Heating

With hydrogenchloride; sodium azide; oxalyl dichloride; hydrogen; potassium carbonate; acetic acid; N,N-dimethyl-formamide; palladium; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0205090

Reference yield:

: 221560-09-4
2,4-Difluoro-5-nitrobenzoyl Chloride

: 179741-37-8
1-(3-amino-4,6-difluorophenyl)-6,7-difluoro-8-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: sodium azide / CH₂Cl₂; dimethylformamide / 0.33 h / 20 °C

2: 149 g / CH₂Cl₂; dimethylformamide / 2 h / Heating

3: 75 percent / H₂ / palladium black / methanol / 72 h / 20 °C

4: CH₂Cl₂ / 20 °C

5: K₂CO₃ / dimethylformamide / 80 °C

6: 96 percent / AcOH; aq. HCl / Heating

With hydrogenchloride; sodium azide; hydrogen; potassium carbonate; acetic acid; palladium; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0205090