(S,Z)-2-(5-(4-(2-(4-fluorophenyl)-2-oxoethoxy)benzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid

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Chemical Name:(S,Z)-2-(5-(4-(2-(4-fluorophenyl)-2-oxoethoxy)benzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid
CAS No.:1393891-23-0
Molecular Formula:C₂₇H₂₀FNO₅S₂
Molecular Weight:521.59
Hs Code.:

Synonyms:(S,Z)-2-(5-(4-(2-(4-fluorophenyl)-2-oxoethoxy)benzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid

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Chemical Property of (S,Z)-2-(5-(4-(2-(4-fluorophenyl)-2-oxoethoxy)benzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid

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Technology Process of (S,Z)-2-(5-(4-(2-(4-fluorophenyl)-2-oxoethoxy)benzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid

There total 3 articles about (S,Z)-2-(5-(4-(2-(4-fluorophenyl)-2-oxoethoxy)benzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 161192-25-2
(S)-2-(4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid

: 901414-58-2
C₁₅H₁₁FO₃

: 1393891-23-0
(S,Z)-2-(5-(4-(2-(4-fluorophenyl)-2-oxoethoxy)benzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid

Guidance literature:: With piperidine; acetic acid; In ethanol; for 4h; Reflux;
DOI:10.1016/j.ejmech.2012.05.023

Reference yield:

: 403-42-9
1-(4-fluorophenyl)ethanone

: 1393891-23-0
(S,Z)-2-(5-(4-(2-(4-fluorophenyl)-2-oxoethoxy)benzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid; N,N'-dibromohydantoin / methanol / 8 h / 30 °C

2: acetone / 20 °C

3: piperidine; acetic acid / ethanol / 4 h / Reflux

With piperidine; toluene-4-sulfonic acid; acetic acid; N,N'-dibromohydantoin; In methanol; ethanol; acetone; 3: Knoevenagel condensation;
DOI:10.1016/j.ejmech.2012.05.023

Reference yield:

: 403-29-2
2-bromo-4'-fluoroacetophenone

: 1393891-23-0
(S,Z)-2-(5-(4-(2-(4-fluorophenyl)-2-oxoethoxy)benzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: acetone / 20 °C

2: piperidine; acetic acid / ethanol / 4 h / Reflux

With piperidine; acetic acid; In ethanol; acetone; 2: Knoevenagel condensation;
DOI:10.1016/j.ejmech.2012.05.023