2-Phenylbenzhydrazide

Base Information

• Chemical Name: 2-Phenylbenzhydrazide
• CAS No.: 154660-48-7
• Molecular Formula: C13H12N2O
• Molecular Weight: 212.251
• Hs Code.: 2928000090
• European Community (EC) Number: 673-724-3
• DSSTox Substance ID: DTXSID10375135
• Wikidata: Q82163670
• Mol file: 154660-48-7.mol

Synonyms:2-Phenylbenzhydrazide;154660-48-7;2-phenylbenzohydrazide;[1,1'-biphenyl]-2-carbohydrazide;2-biphenylcarboxylic hydrazide;2-biphenylcarboxylic acid hydrazide;Biphenyl-2-carbohydrazide;2-phenylbenzoylhydrazine;1,5-Biphenylcarbohydrazide;2-phenylbenzoic acid hydrazide;SCHEMBL1826396;DTXSID10375135;URSYVWKUCWNLMA-UHFFFAOYSA-N;biphenyl-2-carboxylic acid-hydrazide;MFCD00270122;AKOS005216885;AC-7812;SB85977;BS-25215;CS-0447196;FT-0682121;A809560

Chemical Property of 2-Phenylbenzhydrazide

Chemical Property:

• Melting Point: 140 °C
• Refractive Index: 1.612
• PKA: 12.49±0.10(Predicted)
• PSA: 55.12000
• Density: 1.164 g/cm³
• LogP: 3.04830
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 212.094963011
• Heavy Atom Count: 16
• Complexity: 236

Purity/Quality:

98%Min ^*data from raw suppliers

2-Phenylbenzhydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:
• Hazard Codes: R36/37/38:
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC=CC=C2C(=O)NN

Technology Process of 2-Phenylbenzhydrazide

There total 4 articles about 2-Phenylbenzhydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.5%

biphenyl-2-carboxylic acid methyl ester (16605-99-5) → [1,1′-biphenyl]-2-carbohydrazide (154660-48-7)

Guidance literature:

With hydrazine hydrate; In ethanol; for 21h; Heating;

Reference yield:

2-phenylbenzoic acid ethyl ester (19926-49-9) → [1,1′-biphenyl]-2-carbohydrazide (154660-48-7)

Guidance literature:

With hydrazine hydrate; In neat (no solvent); at 120 ℃; Sealed tube;

DOI:10.1002/cmdc.201700186

Reference yield:

2-Biphenylcarboxylic acid (947-84-2) → [1,1′-biphenyl]-2-carbohydrazide (154660-48-7)

Guidance literature:

Multi-step reaction with 2 steps

1: BF₃*Et₂O

2: NH₂NH₂

With boron trifluoride diethyl etherate; hydrazine;

upstream raw materials:

biphenyl-2-carboxylic acid methyl ester

2-Biphenylcarboxylic acid

2-phenylbenzoic acid ethyl ester

Downstream raw materials:

N-(2-phenylbenzoyl)-N'-benzensulfonylhydrazine

6(5H)-phenanthridinone

Biphenyl-2-carboxylic acid (3-trifluoromethyl-benzylidene)-hydrazide

9-fluorenone

Refernces

• 1、 Joly, Nicolas,Bettoni, Léo,Gaillard, Sylvain,Poater, Albert,Renaud, Jean-Luc. "Phosphine-free ruthenium complex-catalyzed synthesis of mono- Or dialkylated acyl hydrazides via the borrowing hydrogen strategy". . p. 6813 - 6825. Retrieved 2021/05/29.
• 2、 Becker, Katja,Benvenuti, Manuela,Bossis, Guillaume,Conde, Pierre-Alexis,Crowder, Michael W.,Dillenberger, Melissa,Docquier, Jean-Denis,Gavara, Laurent,Hernandez, Jean-Fran?ois,Legru, Alice,Mangani, Stefano,Pozzi, Cecilia,Sannio, Filomena,Tassone, Giusy,Thomas, Caitlyn A.,Verdirosa, Federica. "1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity". . . Retrieved 2021/10/12.