(2S,4S)-4-Cyano-2-(5-{4'-[2-((2S,5S)-5-methoxycarbonylamino-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-2-yl)-3H-imidazol-4-yl]-biphenyl-4-yl}-1H-imidazol-2-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(2S,4S)-4-Cyano-2-(5-{4'-[2-((2S,5S)-5-methoxycarbonylamino-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-2-yl)-3H-imidazol-4-yl]-biphenyl-4-yl}-1H-imidazol-2-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:1399845-10-3
Molecular Formula:C₄₂H₄₂N₈O₅
Molecular Weight:738.846
Hs Code.:

(2S,4S)-4-Cyano-2-(5-{4'-[2-((2S,5S)-5-methoxycarbonylamino-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-2-yl)-3H-imidazol-4-yl]-biphenyl-4-yl}-1H-imidazol-2-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Synonyms:(2S,4S)-4-Cyano-2-(5-{4'-[2-((2S,5S)-5-methoxycarbonylamino-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-2-yl)-3H-imidazol-4-yl]-biphenyl-4-yl}-1H-imidazol-2-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of (2S,4S)-4-Cyano-2-(5-{4'-[2-((2S,5S)-5-methoxycarbonylamino-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-2-yl)-3H-imidazol-4-yl]-biphenyl-4-yl}-1H-imidazol-2-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of (2S,4S)-4-Cyano-2-(5-{4'-[2-((2S,5S)-5-methoxycarbonylamino-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-2-yl)-3H-imidazol-4-yl]-biphenyl-4-yl}-1H-imidazol-2-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 12 articles about (2S,4S)-4-Cyano-2-(5-{4'-[2-((2S,5S)-5-methoxycarbonylamino-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-2-yl)-3H-imidazol-4-yl]-biphenyl-4-yl}-1H-imidazol-2-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1399843-34-5
{(2S,5S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-5-yl}-carbamic acid methyl ester

: 1256390-80-3
(2S,4S)-4-cyano-2-{5-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1399845-10-3
(2S,4S)-4-Cyano-2-(5-{4'-[2-((2S,5S)-5-methoxycarbonylamino-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-2-yl)-3H-imidazol-4-yl]-biphenyl-4-yl}-1H-imidazol-2-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With potassium phosphate; palladium diacetate; ruphos; In water; butan-1-ol; at 90 ℃; for 3h; Sealed tube; Inert atmosphere;

Reference yield:

: 204326-24-9
(2S,11S)-11-([[(9H-fluoren-9-yl)methoxy]carbonyl]amino)-12-oxo-1-azatricyclo[6.4.1.0^[4,13]]trideca-4⁽¹³⁾,5,7-triene-2-carboxylic acid

: 1399845-10-3
(2S,4S)-4-Cyano-2-(5-{4'-[2-((2S,5S)-5-methoxycarbonylamino-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-2-yl)-3H-imidazol-4-yl]-biphenyl-4-yl}-1H-imidazol-2-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: piperidine / N,N-dimethyl-formamide / 1 h / 20 °C

2: sodium hydroxide; sodium carbonate / water / 3 h / 20 °C / Cooling with ice

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; ammonium acetate / xylene / 3 h / 140 °C / Inert atmosphere; Sealed tube

5: potassium phosphate / palladium diacetate; ruphos / butan-1-ol; water / 3 h / 90 °C / Sealed tube; Inert atmosphere

With piperidine; potassium phosphate; ammonium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium diacetate; ruphos; In water; N,N-dimethyl-formamide; acetonitrile; xylene; butan-1-ol;

Reference yield:

: 1399843-33-4
{(2S,5S)-2-[2-(4-bromo-phenyl)-2-oxo-ethylcarbamoyl]-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-5-yl}-carbamic acid methyl ester

: 1399845-10-3
(2S,4S)-4-Cyano-2-(5-{4'-[2-((2S,5S)-5-methoxycarbonylamino-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-2-yl)-3H-imidazol-4-yl]-biphenyl-4-yl}-1H-imidazol-2-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium acetate / xylene / 4 h / 140 °C / Sealed tube

2: potassium phosphate / palladium diacetate; ruphos / butan-1-ol; water / 3 h / 90 °C / Sealed tube; Inert atmosphere

With potassium phosphate; ammonium acetate; palladium diacetate; ruphos; In water; xylene; butan-1-ol;