methyl (2S,5S)-2-(4-(4-bromophenyl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate

Base Information

Chemical Name:methyl (2S,5S)-2-(4-(4-bromophenyl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate
CAS No.:1399843-34-5
Molecular Formula:C₂₃H₂₁BrN₄O₃
Molecular Weight:481.349
Hs Code.:

Synonyms:methyl (2S,5S)-2-(4-(4-bromophenyl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate

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Chemical Property of methyl (2S,5S)-2-(4-(4-bromophenyl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate

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Technology Process of methyl (2S,5S)-2-(4-(4-bromophenyl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate

There total 7 articles about methyl (2S,5S)-2-(4-(4-bromophenyl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1399843-33-4
{(2S,5S)-2-[2-(4-bromo-phenyl)-2-oxo-ethylcarbamoyl]-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-5-yl}-carbamic acid methyl ester

: 1399843-34-5
{(2S,5S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-5-yl}-carbamic acid methyl ester

Guidance literature:: With ammonium acetate; In xylene; at 140 ℃; for 4h; Product distribution / selectivity; Sealed tube;

Reference yield: 55.0%

: 1399845-02-3
(2S,5S)-5-Methoxycarbonylamino-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indole-2-carboxylic acid 2-(4-bromo-phenyl)-2-oxo-ethyl ester

: 1399843-34-5
{(2S,5S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-5-yl}-carbamic acid methyl ester

Guidance literature:: With ammonium acetate; N-ethyl-N,N-diisopropylamine; In xylene; at 140 ℃; for 3h; Inert atmosphere; Sealed tube;

Reference yield:

: 5-(S)-amino-1,2,4,5,6,7-hexahydro-azepino <3,2,1-hi> indole-4-one-2-(S)-carboxylic acid

: 1399843-34-5
{(2S,5S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-5-yl}-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; sodium carbonate / water / 3 h / 20 °C / Cooling with ice

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; ammonium acetate / xylene / 3 h / 140 °C / Inert atmosphere; Sealed tube

With ammonium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In water; acetonitrile; xylene;