4-(Diethoxymethyl)phenylmagnesium bromide

Base Information

• Chemical Name: 4-(Diethoxymethyl)phenylmagnesium bromide
• CAS No.: 133292-05-4
• Molecular Formula: C₁₁H₁₅BrMgO₂
• Molecular Weight: 283.448
• European Community (EC) Number: 664-264-4
• Mol file: 133292-05-4.mol

Synonyms:4-(Diethoxymethyl)phenylmagnesium bromide;133292-05-4;4-(Diethoxymethyl)phenylmagnesium bromide, 1.0 M in THF;MFCD11553216;magnesium;diethoxymethylbenzene;bromide;SCHEMBL3397761;APPJPCOJOCVSMA-UHFFFAOYSA-M;4-diethoxymethylphenylmagnesium bromide;4-(Diethoxymethyl)phenylmagnesium bromide, 1.0 M in 2-MeTHF

Chemical Property of 4-(Diethoxymethyl)phenylmagnesium bromide

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 282.01058
• Heavy Atom Count: 15
• Complexity: 215

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC(C1=CC=[C-]C=C1)OCC.[Mg+2].[Br-]

Technology Process of 4-(Diethoxymethyl)phenylmagnesium bromide

There total 1 articles about 4-(Diethoxymethyl)phenylmagnesium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromobenzaldehyde diethyl acetal (34421-94-8) → 4-(diethoxymethyl)phenylmagnesium bromide (133292-05-4)

Guidance literature:

With magnesium; iodine; In tetrahydrofuran; for 4h; Heating;

DOI:10.1080/15421400701709785

Reference yield: 76.0%

2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline (78317-83-6) + 4-(diethoxymethyl)phenylmagnesium bromide (133292-05-4) → 1-[4-(diethoxymethyl)phenyl]-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline (1445853-43-9)

Guidance literature:

2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline; With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In chlorobenzene; at 20 ℃; for 0.166667h; Inert atmosphere;

4-(diethoxymethyl)phenylmagnesium bromide; In tetrahydrofuran; chlorobenzene; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ol401534g

Reference yield: 56.0%

methyl-3-pyridylketone (350-03-8) + 4-(diethoxymethyl)phenylmagnesium bromide (133292-05-4) → 4-<1-(3-pyridyl)-1-hydroxyethyl>benzaldehyde diethyl acetal (75986-20-8)

Guidance literature:

In tetrahydrofuran; for 1h; Ambient temperature;

DOI:10.1021/jm00142a006

upstream raw materials:

4-bromobenzaldehyde diethyl acetal

Downstream raw materials:

4-<1-(3-pyridyl)-1-hydroxyethyl>benzaldehyde diethyl acetal

4-(3-pyridylmethyl)benzaldehyde diethyl acetal

4-(1-Pyridin-3-yl-vinyl)-benzaldehyde

4-Pyridin-3-ylmethyl-benzaldehyde