Technology Process of tert-butyl 3-(1-(3-(allyloxy)benzoyl)piperidin-4-yl)benzylcarbamate
There total 10 articles about tert-butyl 3-(1-(3-(allyloxy)benzoyl)piperidin-4-yl)benzylcarbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 1 h / -78 °C
1.2: -78 - 20 °C
2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / acetonitrile; water / 1 h / 90 °C
3.1: sodium tetrahydroborate / nickel(II) chloride hexahydrate / methanol / 0 - 20 °C / Cooling with ice
4.1: hydrogen / palladium-on-charcoal / methanol / 1 h
5.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C
With
sodium tetrahydroborate; hydrogen; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide;
tetrakis(triphenylphosphine) palladium(0); nickel(II) chloride hexahydrate; palladium-on-charcoal;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogen / palladium-on-charcoal / methanol / 1 h
2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C
With
hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
palladium-on-charcoal;
In
methanol; dichloromethane;