N⁶-benzoyl-9-(2-O-tert-butyldimethylsilyl-3-deoxy-3-methylene-5-O-trityl-β-D-erythro-pentofuranosyl)adenine

Base Information

• Chemical Name: N⁶-benzoyl-9-(2-O-tert-butyldimethylsilyl-3-deoxy-3-methylene-5-O-trityl-β-D-erythro-pentofuranosyl)adenine
• CAS No.: 289044-88-8
• Molecular Formula: C₄₃H₄₅N₅O₄Si
• Molecular Weight: 723.947

Synonyms:N⁶-benzoyl-9-(2-O-tert-butyldimethylsilyl-3-deoxy-3-methylene-5-O-trityl-β-D-erythro-pentofuranosyl)adenine

Chemical Property of N⁶-benzoyl-9-(2-O-tert-butyldimethylsilyl-3-deoxy-3-methylene-5-O-trityl-β-D-erythro-pentofuranosyl)adenine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁶-benzoyl-9-(2-O-tert-butyldimethylsilyl-3-deoxy-3-methylene-5-O-trityl-β-D-erythro-pentofuranosyl)adenine

There total 5 articles about N⁶-benzoyl-9-(2-O-tert-butyldimethylsilyl-3-deoxy-3-methylene-5-O-trityl-β-D-erythro-pentofuranosyl)adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

benzoyl chloride (98-88-4) + 9-(2-O-tert-butyldimethylsilyl-3-deoxy-3-methylene-5-O-trityl-β-D-erythro-pentofuranosyl)adenine (289044-87-7) → N6-benzoyl-9-(2-O-tert-butyldimethylsilyl-3-deoxy-3-methylene-5-O-trityl-β-D-erythro-pentofuranosyl)adenine (289044-88-8)

Guidance literature:

With pyridine; dmap; at 20 ℃; for 2h;

DOI:10.1021/jo0001333

Reference yield:

5'-O-(triphenylmethyl)adenosine (18048-85-6) → N6-benzoyl-9-(2-O-tert-butyldimethylsilyl-3-deoxy-3-methylene-5-O-trityl-β-D-erythro-pentofuranosyl)adenine (289044-88-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 66 percent / AgNO₃; pyridine / tetrahydrofuran / 15 h / 20 °C

2: 16 g / CrO₃; pyridine; further reagents / CH₂Cl₂ / 2 h / 0 - 20 °C

3: 9.2 g / tetrahydrofuran / -78 - 0 °C

4: 95 percent / pyridine; 4-(dimethylamino)pyridine / 2 h / 20 °C

With pyridine; chromium(VI) oxide; dmap; silver nitrate; In tetrahydrofuran; dichloromethane; 1: Substitution / 2: Oxidation / 3: Substitution / 4: Acylation;

DOI:10.1021/jo0001333

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → N6-benzoyl-9-(2-O-tert-butyldimethylsilyl-3-deoxy-3-methylene-5-O-trityl-β-D-erythro-pentofuranosyl)adenine (289044-88-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 66 percent / AgNO₃; pyridine / tetrahydrofuran / 15 h / 20 °C

2: 16 g / CrO₃; pyridine; further reagents / CH₂Cl₂ / 2 h / 0 - 20 °C

3: 9.2 g / tetrahydrofuran / -78 - 0 °C

4: 95 percent / pyridine; 4-(dimethylamino)pyridine / 2 h / 20 °C

With pyridine; chromium(VI) oxide; dmap; silver nitrate; In tetrahydrofuran; dichloromethane; 1: Substitution / 2: Oxidation / 3: Substitution / 4: Acylation;

DOI:10.1021/jo0001333

upstream raw materials:

benzoyl chloride

9-(2-O-tert-butyldimethylsilyl-3-deoxy-3-methylene-5-O-trityl-β-D-erythro-pentofuranosyl)adenine

5'-O-(triphenylmethyl)adenosine

tert-butyldimethylsilyl chloride

Downstream raw materials:

N⁶-benzoyl-9-(2-O-tert-butyldimethylsilyl-3-deoxy-3-methylene-β-D-erythro-pentofuranosyl)adenine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 289044-88-8 N⁶-benzoyl-9-(2-O-tert-butyldimethylsilyl-3-deoxy-3-methylene-5-O-trityl-β-D-erythro-pentofuranosyl)adenine

Send

Send

Metric Ton KG G Pound L ML

Send

Send