trans-phenyl octahydro-4a-(3-methoxyphenyl)-6-methylene-2(1H)-isoquinolinecarboxylate

Base Information

Chemical Name:trans-phenyl octahydro-4a-(3-methoxyphenyl)-6-methylene-2(1H)-isoquinolinecarboxylate
CAS No.:137517-46-5
Molecular Formula:C₂₄H₂₇NO₃
Molecular Weight:377.483
Hs Code.:

Synonyms:trans-phenyl octahydro-4a-(3-methoxyphenyl)-6-methylene-2(1H)-isoquinolinecarboxylate

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Chemical Property of trans-phenyl octahydro-4a-(3-methoxyphenyl)-6-methylene-2(1H)-isoquinolinecarboxylate

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Technology Process of trans-phenyl octahydro-4a-(3-methoxyphenyl)-6-methylene-2(1H)-isoquinolinecarboxylate

There total 4 articles about trans-phenyl octahydro-4a-(3-methoxyphenyl)-6-methylene-2(1H)-isoquinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: trans-decahydro-4a-(3-methoxyphenyl)-2-methyl-6-methyleneisoquinoline

: 1885-14-9
phenyl chloroformate

: 137517-46-5
trans-phenyl octahydro-4a-(3-methoxyphenyl)-6-methylene-2(1H)-isoquinolinecarboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; for 1.5h; Heating;
DOI:10.1021/jm00079a005

Reference yield:

: 82359-61-3
4-bromo-2-(bromomethyl)-1-butene

: 137517-46-5
trans-phenyl octahydro-4a-(3-methoxyphenyl)-6-methylene-2(1H)-isoquinolinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi, 3.) NaI, K₂CO₃

2: 83 percent / 1.) MeSO₃H, 2.) NaBH₄ / methanol / 1.) from -60 to 25 deg C, 5 min, 2.) RT, 30 min

3: 88 percent / i-Pr₂NEt / 1,2-dichloro-ethane / 1.5 h / Heating

With sodium tetrahydroborate; n-butyllithium; methanesulfonic acid; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; In methanol; 1,2-dichloro-ethane;
DOI:10.1021/jm00079a005

Reference yield:

: 73224-22-3
1-methyl-4-(3-methoxyphenyl)-1,2,3,6-tetrahydropyridine

: 137517-46-5
trans-phenyl octahydro-4a-(3-methoxyphenyl)-6-methylene-2(1H)-isoquinolinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi, 3.) NaI, K₂CO₃

2: 83 percent / 1.) MeSO₃H, 2.) NaBH₄ / methanol / 1.) from -60 to 25 deg C, 5 min, 2.) RT, 30 min

3: 88 percent / i-Pr₂NEt / 1,2-dichloro-ethane / 1.5 h / Heating

With sodium tetrahydroborate; n-butyllithium; methanesulfonic acid; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; In methanol; 1,2-dichloro-ethane;
DOI:10.1021/jm00079a005