tert-butyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)picolinate

Base Information

• Chemical Name: tert-butyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)picolinate
• CAS No.: 1097726-89-0
• Molecular Formula: C₂₄H₂₁ClF₃N₃O₄
• Molecular Weight: 507.897
• Mol file: 1097726-89-0.mol

Synonyms:tert-butyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)picolinate

Chemical Property of tert-butyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)picolinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)picolinate

There total 8 articles about tert-butyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)picolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

tert-butyl 4-(4-aminophenoxy)picolinate (1097726-88-9) + 4-chloro-3-(trifluoromethyl)phenyl isocyanate (327-78-6) → tert-butyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)picolinate (1097726-89-0)

Guidance literature:

In dichloromethane; at 20 ℃; for 16h;

Reference yield: 56.0%

tert-butyl 4-(4-aminophenoxy)picolinate (1097726-88-9) + triphosgene + 4-chloro-3-trifluoromethyl-aniline (320-51-4) → tert-butyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)picolinate (1097726-89-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

tert-butyl 4-chloropyridine-2-carboxylate (220000-86-2) → tert-butyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)picolinate (1097726-89-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 2 h / 80 °C

2.1: dichloromethane / 16 h / 20 °C

With potassium tert-butylate; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

tert-butyl 4-(4-aminophenoxy)picolinate

4-chloro-3-(trifluoromethyl)phenyl isocyanate

4-chloro-3-trifluoromethyl-aniline

4-chloropicolinic acid

Downstream raw materials:

4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-2-pyridinecarboxylic acid

N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-(methyl-d₃)aminoformyl)-4-pyridyloxy)phenyl)urea

4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxyl)-2-(N-1’,1’,1’-trideuteromethyl)pyridine amide p-toluenesulfonate

methyl 4‐(4‐(3‐(4‐chloro‐3‐(trifluoromethyl)phenyl)ureido)phenoxy)picolinate