1,1,1,3,3,3-Hexafluoropropan-2-amine

Base Information

• Chemical Name: 1,1,1,3,3,3-Hexafluoropropan-2-amine
• CAS No.: 1619-92-7
• Molecular Formula: C3H3F6N
• Molecular Weight: 167.054
• Hs Code.: 2921199090
• European Community (EC) Number: 692-645-5
• DSSTox Substance ID: DTXSID70481246
• Wikidata: Q81986051
• Mol file: 1619-92-7.mol

Synonyms:1619-92-7;1,1,1,3,3,3-HEXAFLUOROISOPROPYLAMINE;1,1,1,3,3,3-Hexafluoropropan-2-amine;2,2,2-Trifluoro-1-(trifluoromethyl)ethylamine;1,1,1,3,3,3-Hexafluoropropylamine;2-Amino-2H-perfluoropropane;hexafluoroisopropylamine;SCHEMBL396567;DTXSID70481246;MFCD08460498;AKOS006343498;AT19906;1,1,1,3,3,3-hexafluoro-2-propanamine;BS-25556;EN300-715823;1,1,1,3,3,3-hexakis(fluoranyl)propan-2-amine;A810321;J-009882

Chemical Property of 1,1,1,3,3,3-Hexafluoropropan-2-amine

Chemical Property:

• Vapor Pressure: 135mmHg at 25°C
• Refractive Index: 1.282
• Boiling Point: 69.4 °C at 760 mmHg
• PKA: 2.05±0.50(Predicted)
• Flash Point: 7.2 °C
• PSA: 26.02000
• Density: 1.453 g/cm³
• LogP: 2.13860
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 0
• Exact Mass: 167.01696807
• Heavy Atom Count: 10
• Complexity: 97.1

Purity/Quality:

99%, ^*data from raw suppliers

1,1,1,3,3,3-Hexafluoroisopropylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 34
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(F)(F)F)(C(F)(F)F)N

Technology Process of 1,1,1,3,3,3-Hexafluoropropan-2-amine

There total 2 articles about 1,1,1,3,3,3-Hexafluoropropan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

1,1,1,3,4,4,5,5,5-nonafluoro-2-trifluoromethyl-2,3-epoxypentane (788-67-0) → 2,2,3,3,3-pentafluoropropionamide (354-76-7) + 2,2,2-Trifluor-1-(trifluormethyl)ethylamin (1619-92-7)

Guidance literature:

With ammonia; In diethyl ether;

Reference yield:

O-(Fluorodiphenylmethyl)hexafluoroacetone oxime (97218-61-6) → 1,1-Diphenylmethanol (91-01-0) + 2,2,2-Trifluor-1-(trifluormethyl)ethylamin (1619-92-7)

Guidance literature:

With lithium aluminium tetrahydride; In diethylene glycol dimethyl ether; at 0 ℃;

DOI:10.1039/c39850000205

Reference yield: 61.0%

2,2,2-Trifluor-1-(trifluormethyl)ethylamin (1619-92-7) + 7-chloro-4-oxo-1-(2,4,6-trifluorophenyl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid → 7-chloro-N-(1,1,1,3,3,3-hexafluoropropan-2-yl)-4-oxo-1-(2,4,6-trifluorophenyl)-1,4-dihydro-1,8-naphthyridine-3-carboxamide

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In ethyl acetate; N,N-dimethyl-formamide; at 80 ℃;

upstream raw materials:

1,1,1,3,4,4,5,5,5-nonafluoro-2-trifluoromethyl-2,3-epoxypentane

O-(Fluorodiphenylmethyl)hexafluoroacetone oxime

Downstream raw materials:

N-Phenyl-N'-<α-hydro-perfluorisopropyl>-harnstoff

6-chloro-3-(2-(1,1,1,3,3,3-hexafluoropropan-2-ylamino)-3,4-dioxocyclobut-1-enylamino)-2-hydroxy-N-methoxy-N-methylbenzenesulfonamide

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