354-76-7Relevant academic research and scientific papers
Method for preparing perfluorinated nitrile through gas phase catalysis
-
Paragraph 0059; 0060, (2019/02/21)
The invention discloses a method for preparing perfluorinated nitrile through gas phase catalysis. The method comprises the following steps: a, in the absence of a catalyst, enabling acyl fluoride R1COF or perfluor substituted ethylene oxide Cyclo-CF2-CR2R3-O- to perform a gas phase amination reaction with an ammonia gas or a primary amine compound, to obtain amide of which a general formula is R1CONH2 or CR2R3FCONH2, wherein general formulas of R1, R2 and R3 are CnF[2n+1], CxF[2x+1], and CyF[2y+1], wherein x and y are non-negative integer sets, x+y=n, and n is a positive integer set; and b, in the presence of the catalyst, dehydrating the amide R1CONH2, to obtain the perfluorinated nitrile R1CN. The method is short in reaction route, and the perfluor substituted ethylene oxide or the acylfluoride is easily obtained. A total yield of the perfluorinated nitrile is high, and the route is easy for continuous industrialization.
FLUOROALKYL-CONTAINING β,β'-TRICARBONYL COMPOUNDS: TAUTOMERISM AND REACTION WITH N-NUCLEOPHILES
Krokhalev, V. M.,Saloutin, V. I.,Romas', A. D.,Ershov, B. A.,Pashkevich, K. I.
, p. 316 - 322 (2007/10/02)
The tautomeric composition of α-polyfluoroacyl derivatives of acetylacetone and malonic ester has been established and it has been shown that with N-nucleophiles (ammonia, 1,2-ethylenediamine, o-phenylenediamine) these compounds undergo 'acid' decomposition with the elimination of the polyfluoroacyl group.With hydrazines, malonic ester derivatives react similarly but acetylacetone derivatives undergo cyclization into pyrazoles.The regiodirectivity of the interaction of fluoroalkyl-containing β,β'-tricarbonyl compounds with N-nucleophiles does not depend on their tautomeric composition and is determined by orbital control.
REACTION OF INTERNAL PERFLUORINATED α-OXIDES WITH AMMONIA
Saloutina, L. V.,Zapevalov, A. Ya.,Kodess, M. I.,Kolenko, I. P.
, p. 628 - 634 (2007/10/02)
The action of ammonia leads to nucleophilic opening of the epoxide ring in internal perfluorinated α oxides with the formation of aminoiminoperfluoroalkanols and their dissociation products.In unsymmetrical disubstituted 2,3-epoxyperfluoroalkanes attack by ammonia at the carbon atoms of the epoxide ring is not regioselective, whereas in the trisubstituted compounds regiospecific reaction with ammonia occurs.The stability of the internal perfluorinated α-oxides to the action of ammonia is increased with increase in the size of the fluoroalkyl substituents.
SYNTHESIS AND REACTIONS OF OXYGEN CONTAINING ORGANOFLUORINE COMPOUNDS. IX. REACTION OF POLYFLUOROALKYL KETONES WITH AMMONIA
Saloutina, L. V.,Zapevalov, A. Ya.,Kolenko, I. P.
, p. 2019 - 2024 (2007/10/02)
The reaction of polyfluoroalkyl ketones with ammonia at reduced temperature was studied.The products from addition of ammonia at the carbonyl group, i.e., geminal amino alkohols, were obtained.If there are chlorine and bromine atoms at the α position, the polyfluoroalkyl ketones dissociate under the influence of ammonia to carboxamides and polyhalogenoalkanes.
