N¹⁴-methyl-7,14-diaza-8,15-dioxo-18-methyloxycarbonyl-18-benzyloxycarbonylamino-18-(S)-octadecanoic acid

Base Information

• Chemical Name: N¹⁴-methyl-7,14-diaza-8,15-dioxo-18-methyloxycarbonyl-18-benzyloxycarbonylamino-18-(S)-octadecanoic acid
• CAS No.: 1427040-28-5
• Molecular Formula: C₂₇H₄₁N₃O₈
• Molecular Weight: 535.638

Synonyms:N¹⁴-methyl-7,14-diaza-8,15-dioxo-18-methyloxycarbonyl-18-benzyloxycarbonylamino-18-(S)-octadecanoic acid

Chemical Property of N¹⁴-methyl-7,14-diaza-8,15-dioxo-18-methyloxycarbonyl-18-benzyloxycarbonylamino-18-(S)-octadecanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N¹⁴-methyl-7,14-diaza-8,15-dioxo-18-methyloxycarbonyl-18-benzyloxycarbonylamino-18-(S)-octadecanoic acid

There total 7 articles about N¹⁴-methyl-7,14-diaza-8,15-dioxo-18-methyloxycarbonyl-18-benzyloxycarbonylamino-18-(S)-octadecanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

N7-methyl-7-aza-8-oxo-11-methyloxycarbonyl-11-benzyloxycarbonylamino-11-(S)-unecanoic acid + 6-aminohexanoic acid (60-32-2,93208-38-9) → N14-methyl-7,14-diaza-8,15-dioxo-18-methyloxycarbonyl-18-benzyloxycarbonylamino-18-(S)-octadecanoic acid (1427040-28-5)

Guidance literature:

N⁷-methyl-7-aza-8-oxo-11-methyloxycarbonyl-11-benzyloxycarbonylamino-11-(S)-unecanoic acid; With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In acetonitrile; at 20 ℃; for 16h;

6-aminohexanoic acid; With sodium hydroxide; In water; acetonitrile; at 20 ℃; for 4h; pH=8;

DOI:10.1021/jm301831f

Reference yield:

N-benzyloxycarbonyl-L-glutamic acid (1155-62-0) → N14-methyl-7,14-diaza-8,15-dioxo-18-methyloxycarbonyl-18-benzyloxycarbonylamino-18-(S)-octadecanoic acid (1427040-28-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: dicyclohexyl-carbodiimide / tetrahydrofuran / 144 h / 20 °C

2.1: dichloromethane / 20 °C

3.1: dicyclohexyl-carbodiimide; 1-hydroxy-pyrrolidine-2,5-dione / acetonitrile / 16 h / 20 °C

3.2: 3 h / 20 °C / pH 8

4.1: dicyclohexyl-carbodiimide; 1-hydroxy-pyrrolidine-2,5-dione / acetonitrile / 16 h / 20 °C

4.2: 4 h / 20 °C / pH 8

With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1021/jm301831f

Reference yield:

L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) → N14-methyl-7,14-diaza-8,15-dioxo-18-methyloxycarbonyl-18-benzyloxycarbonylamino-18-(S)-octadecanoic acid (1427040-28-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydroxide / 1,2-dimethoxyethane; water; ethanol / pH 9

2.1: dicyclohexyl-carbodiimide / tetrahydrofuran / 144 h / 20 °C

3.1: dichloromethane / 20 °C

4.1: dicyclohexyl-carbodiimide; 1-hydroxy-pyrrolidine-2,5-dione / acetonitrile / 16 h / 20 °C

4.2: 3 h / 20 °C / pH 8

5.1: dicyclohexyl-carbodiimide; 1-hydroxy-pyrrolidine-2,5-dione / acetonitrile / 16 h / 20 °C

5.2: 4 h / 20 °C / pH 8

With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; sodium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; acetonitrile;

DOI:10.1021/jm301831f

upstream raw materials:

L-glutamic acid

1-methyl-2-azepanone

6-aminohexanoic acid

benzyl chloroformate

Downstream raw materials:

1-[5-[[N,N′-bis[3,10,17-triaza-4,11,18-trioxo-21-methyloxycarbonyl-21-benzyloxycarbonyl-N-methylaminoeinecosane]]aminocarbonyl]pentyl]-1,4,7,10-tetraazacyclododecane-4,7,10-triacetic (1,1-dimethylethyl ester)

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1427040-28-5 N¹⁴-methyl-7,14-diaza-8,15-dioxo-18-methyloxycarbonyl-18-benzyloxycarbonylamino-18-(S)-octadecanoic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send