10-methoxycamptothecin-20-O-2-(tert-butoxycarbonylamino)-3-phenylpropanoic acid ester

Base Information

Chemical Name:10-methoxycamptothecin-20-O-2-(tert-butoxycarbonylamino)-3-phenylpropanoic acid ester
CAS No.:1394865-84-9
Molecular Formula:C₃₅H₃₅N₃O₈
Molecular Weight:625.678
Hs Code.:

Synonyms:10-methoxycamptothecin-20-O-2-(tert-butoxycarbonylamino)-3-phenylpropanoic acid ester

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Chemical Property of 10-methoxycamptothecin-20-O-2-(tert-butoxycarbonylamino)-3-phenylpropanoic acid ester

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Technology Process of 10-methoxycamptothecin-20-O-2-(tert-butoxycarbonylamino)-3-phenylpropanoic acid ester

There total 2 articles about 10-methoxycamptothecin-20-O-2-(tert-butoxycarbonylamino)-3-phenylpropanoic acid ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 19685-10-0
10-methoxycamptothecin

: 1394865-84-9
10-methoxycamptothecin-20-O-2-(tert-butoxycarbonylamino)-3-phenylpropanoic acid ester

Guidance literature:: With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 19685-09-7,64439-81-2
(S)-10-hydroxycamptothecin

: 1394865-84-9
10-methoxycamptothecin-20-O-2-(tert-butoxycarbonylamino)-3-phenylpropanoic acid ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 12.5 h / 20 °C

2: dmap; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

With dmap; potassium carbonate; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; acetone;
DOI:10.14233/ajchem.2015.17599