(S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-nitrophenoxy)phenyl)propanoic acid

Base Information

Chemical Name:(S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-nitrophenoxy)phenyl)propanoic acid
CAS No.:914639-63-7
Molecular Formula:C₂₀H₂₂N₂O₇
Molecular Weight:402.404
Hs Code.:

Synonyms:(S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-nitrophenoxy)phenyl)propanoic acid

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Chemical Property of (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-nitrophenoxy)phenyl)propanoic acid

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Technology Process of (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-nitrophenoxy)phenyl)propanoic acid

There total 4 articles about (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-nitrophenoxy)phenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.5%

: 3978-80-1
Boc-Tyr-OH

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 914639-63-7
(S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-nitrophenoxy)phenyl)propanoic acid

Guidance literature:: Boc-Tyr-OH; 4-Fluoronitrobenzene; With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 15h;

With hydrogenchloride; water; pH=2;

Reference yield:

: 914639-64-8
(2S)-2-[(t-butoxycarbonyl)amino]-3-[4-(4-nitrophenoxy)phenyl]propanoic acid methyl ester

: 914639-63-7
(S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-nitrophenoxy)phenyl)propanoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 60 - 80 ℃; for 1.5h;
DOI:10.1016/j.bmc.2016.10.020

Reference yield:

: 60-18-4,18875-48-4,25619-78-7,30704-25-7
L-tyrosine

: 914639-63-7
(S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-nitrophenoxy)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetyl chloride / 0.5 h / Cooling with ice

1.2: 4 h / Reflux

2.1: potassium carbonate / 1,4-dioxane; water / 20 °C

3.1: potassium carbonate / dimethyl sulfoxide / 30 °C

4.1: sodium hydroxide / tetrahydrofuran / 1.5 h / 60 - 80 °C

With potassium carbonate; acetyl chloride; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide; 3.1: |Williamson Ether Synthesis;
DOI:10.1016/j.bmc.2016.10.020