ethyl 4-(6-(4-chlorophenyl)-9-(methoxymethyl)-2-(trimethylsilyl)-9H-purin-8-yl)benzoate

Base Information

Chemical Name:ethyl 4-(6-(4-chlorophenyl)-9-(methoxymethyl)-2-(trimethylsilyl)-9H-purin-8-yl)benzoate
CAS No.:1265222-02-3
Molecular Formula:C₂₅H₂₇ClN₄O₃Si
Molecular Weight:495.053
Hs Code.:

Synonyms:ethyl 4-(6-(4-chlorophenyl)-9-(methoxymethyl)-2-(trimethylsilyl)-9H-purin-8-yl)benzoate

Suppliers and Price of ethyl 4-(6-(4-chlorophenyl)-9-(methoxymethyl)-2-(trimethylsilyl)-9H-purin-8-yl)benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 4-(6-(4-chlorophenyl)-9-(methoxymethyl)-2-(trimethylsilyl)-9H-purin-8-yl)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 4-(6-(4-chlorophenyl)-9-(methoxymethyl)-2-(trimethylsilyl)-9H-purin-8-yl)benzoate

There total 5 articles about ethyl 4-(6-(4-chlorophenyl)-9-(methoxymethyl)-2-(trimethylsilyl)-9H-purin-8-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 637-87-6
1-Chloro-4-iodobenzene

: 1265221-96-2
ethyl 4-(9-(methoxymethyl)-2-(trimethylsilyl)-9H-purin-8-yl)benzoate

: 1265222-02-3
ethyl 4-(6-(4-chlorophenyl)-9-(methoxymethyl)-2-(trimethylsilyl)-9H-purin-8-yl)benzoate

Guidance literature:: ethyl 4-(9-(methoxymethyl)-2-(trimethylsilyl)-9H-purin-8-yl)benzoate; With zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex; In tetrahydrofuran; at 90 ℃; for 2h; Inert atmosphere; Microwave irradiation;

1-Chloro-4-iodobenzene; With trifuran-2-yl-phosphane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at 25 ℃; for 8h; Inert atmosphere;
DOI:10.1021/ol103057k

Reference yield:

: 6504-64-9
6-chloro-9-(methoxymethyl)-9H-purine

: 1265222-02-3
ethyl 4-(6-(4-chlorophenyl)-9-(methoxymethyl)-2-(trimethylsilyl)-9H-purin-8-yl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 3 h / -78 °C / Inert atmosphere

1.2: 1.33 h / -78 °C / Inert atmosphere

2.1: zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex / tetrahydrofuran / 0.25 h / 25 °C / Inert atmosphere

2.2: 14 h / 45 °C / Inert atmosphere

3.1: palladium on carbon; ammonium formate / methanol; ethanol / 0.5 h / 45 °C / Inert atmosphere

4.1: zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex / tetrahydrofuran / 2 h / 90 °C / Inert atmosphere; Microwave irradiation

4.2: 8 h / 25 °C / Inert atmosphere

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex; palladium on carbon; ammonium formate; In tetrahydrofuran; methanol; ethanol; hexane; 2.2: Negishi coupling reaction / 4.2: Negishi coupling reaction;
DOI:10.1021/ol103057k

Reference yield:

: 1265221-92-8
ethyl 4-(6-chloro-9-(methoxymethyl)-2-(trimethylsilyl)-9H-purin-8-yl)benzoate

: 1265222-02-3
ethyl 4-(6-(4-chlorophenyl)-9-(methoxymethyl)-2-(trimethylsilyl)-9H-purin-8-yl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium on carbon; ammonium formate / methanol; ethanol / 0.5 h / 45 °C / Inert atmosphere

2.1: zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex / tetrahydrofuran / 2 h / 90 °C / Inert atmosphere; Microwave irradiation

2.2: 8 h / 25 °C / Inert atmosphere

With zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex; palladium on carbon; ammonium formate; In tetrahydrofuran; methanol; ethanol; 2.2: Negishi coupling reaction;
DOI:10.1021/ol103057k