tert-butyl 4-cyano-4-(3-fluoro-2-hydroxyphenyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-cyano-4-(3-fluoro-2-hydroxyphenyl)piperidine-1-carboxylate
CAS No.:1292306-52-5
Molecular Formula:C₁₇H₂₁FN₂O₃
Molecular Weight:320.364
Hs Code.:

Synonyms:tert-butyl 4-cyano-4-(3-fluoro-2-hydroxyphenyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-cyano-4-(3-fluoro-2-hydroxyphenyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-cyano-4-(3-fluoro-2-hydroxyphenyl)piperidine-1-carboxylate

There total 7 articles about tert-butyl 4-cyano-4-(3-fluoro-2-hydroxyphenyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1292306-54-7
tert-butyl 4-(2-(benzyloxy)-3-fluorophenyl)-4-cyanopiperidine-1-carboxylate

: 1292306-52-5
tert-butyl 4-cyano-4-(3-fluoro-2-hydroxyphenyl)piperidine-1-carboxylate

Guidance literature:: With hydrogen; 10% palladium on charcoal; In ethyl acetate; at 20 ℃; for 3h;

Reference yield:

: 148872-79-1
3-fluoro-2-[(phenylmethyl)oxy]benzoic acid

: 1292306-52-5
tert-butyl 4-cyano-4-(3-fluoro-2-hydroxyphenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate; methanol / 18 h / 0 - 20 °C

2: Hexamethylphosphorous triamide; tetrachloromethane / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

3: N,N-dimethyl-formamide / 18 h / 20 °C

4: sodium hydride / N,N-dimethyl-formamide; Pionier 2076 / 5.5 h / 20 - 80 °C / Inert atmosphere

5: hydrogen / 10% palladium on charcoal / ethyl acetate / 3 h / 20 °C

With methanol; tetrachloromethane; sodium tetrahydroborate; hydrogen; sodium hydride; Hexamethylphosphorous triamide; 10% palladium on charcoal; In tetrahydrofuran; Pionier 2076; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1292306-52-5
tert-butyl 4-cyano-4-(3-fluoro-2-hydroxyphenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / acetonitrile; water / 18 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide; Pionier 2076 / 5.5 h / 20 - 80 °C / Inert atmosphere

3: hydrogen / 10% palladium on charcoal / ethyl acetate / 3 h / 20 °C

With hydrogen; sodium hydride; sodium hydroxide; 10% palladium on charcoal; In Pionier 2076; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;