tert-butyl 4-(2-(benzyloxy)-3-fluorophenyl)-4-cyanopiperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(2-(benzyloxy)-3-fluorophenyl)-4-cyanopiperidine-1-carboxylate
CAS No.:1292306-54-7
Molecular Formula:C₂₄H₂₇FN₂O₃
Molecular Weight:410.488
Hs Code.:

Synonyms:tert-butyl 4-(2-(benzyloxy)-3-fluorophenyl)-4-cyanopiperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(2-(benzyloxy)-3-fluorophenyl)-4-cyanopiperidine-1-carboxylate

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Technology Process of tert-butyl 4-(2-(benzyloxy)-3-fluorophenyl)-4-cyanopiperidine-1-carboxylate

There total 7 articles about tert-butyl 4-(2-(benzyloxy)-3-fluorophenyl)-4-cyanopiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1292306-54-7
tert-butyl 4-(2-(benzyloxy)-3-fluorophenyl)-4-cyanopiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / acetonitrile; water / 18 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide; Pionier 2076 / 5.5 h / 20 - 80 °C / Inert atmosphere

With sodium hydride; sodium hydroxide; In Pionier 2076; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 148872-79-1
3-fluoro-2-[(phenylmethyl)oxy]benzoic acid

: 1292306-54-7
tert-butyl 4-(2-(benzyloxy)-3-fluorophenyl)-4-cyanopiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate; methanol / 18 h / 0 - 20 °C

2: Hexamethylphosphorous triamide; tetrachloromethane / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

3: N,N-dimethyl-formamide / 18 h / 20 °C

4: sodium hydride / N,N-dimethyl-formamide; Pionier 2076 / 5.5 h / 20 - 80 °C / Inert atmosphere

With methanol; tetrachloromethane; sodium tetrahydroborate; sodium hydride; Hexamethylphosphorous triamide; In tetrahydrofuran; Pionier 2076; N,N-dimethyl-formamide;

Reference yield:

: 628330-74-5
2-benzyloxy-3-fluorobenzyl alcohol

: 1292306-54-7
tert-butyl 4-(2-(benzyloxy)-3-fluorophenyl)-4-cyanopiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: Hexamethylphosphorous triamide; tetrachloromethane / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

2: N,N-dimethyl-formamide / 18 h / 20 °C

3: sodium hydride / N,N-dimethyl-formamide; Pionier 2076 / 5.5 h / 20 - 80 °C / Inert atmosphere

With tetrachloromethane; sodium hydride; Hexamethylphosphorous triamide; In tetrahydrofuran; Pionier 2076; N,N-dimethyl-formamide;