tert-butyl (1-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidin-4-yl)carbamate

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Chemical Name:tert-butyl (1-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidin-4-yl)carbamate
CAS No.:1393901-38-6
Molecular Formula:C₃₁H₃₇F₃N₆O₃
Molecular Weight:598.668
Hs Code.:

Synonyms:tert-butyl (1-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidin-4-yl)carbamate

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Chemical Property of tert-butyl (1-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidin-4-yl)carbamate

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Technology Process of tert-butyl (1-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidin-4-yl)carbamate

There total 11 articles about tert-butyl (1-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidin-4-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1393901-37-5
methyl 2-(2-(2-(2-((4-(4-((tert-butoxycarbonyl)amino)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetate

: 1393901-38-6
tert-butyl (1-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidin-4-yl)carbamate

Guidance literature:: methyl 2-(2-(2-(2-((4-(4-((tert-butoxycarbonyl)amino)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetate; With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; at 20 ℃; for 6h;

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Inert atmosphere;

With ammonium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 72h;

Reference yield:

: 1393901-36-4
methyl 2-(2-((2-((4-(4-((tert-butoxycarbonyl)amino)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl)acetate

: 1393901-38-6
tert-butyl (1-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidin-4-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; hydrogen / 10 wt% Pd(OH)2 on carbon / N,N-dimethyl-formamide / 20 °C

2: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 16 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; ammonium carbonate / N,N-dimethyl-formamide; tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; water; hydrogen; ammonium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; 10 wt% Pd(OH)2 on carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1393901-38-6
tert-butyl (1-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidin-4-yl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.25 h / 150 °C / microwave irradiation

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; N,N-dimethyl-formamide; ethanol / 18 h / 20 °C / sealed tube

3.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.67 h / 0 °C

3.2: 18 h / 0 - 20 °C

4.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / microwave irradiation

5.1: triethylamine; hydrogen / 10 wt% Pd(OH)2 on carbon / N,N-dimethyl-formamide / 20 °C

6.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 16 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; ammonium carbonate / N,N-dimethyl-formamide; tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; water; hydrogen; ammonium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; zinc(II) chloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; 10 wt% Pd(OH)2 on carbon; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; ethanol; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;