methyl 2-(2-((2-((4-(4-((tert-butoxycarbonyl)amino)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl)acetate

Base Information

Chemical Name:methyl 2-(2-((2-((4-(4-((tert-butoxycarbonyl)amino)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl)acetate
CAS No.:1393901-36-4
Molecular Formula:C₃₂H₃₄F₃N₅O₄
Molecular Weight:609.648
Hs Code.:

Synonyms:methyl 2-(2-((2-((4-(4-((tert-butoxycarbonyl)amino)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl)acetate

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Chemical Property of methyl 2-(2-((2-((4-(4-((tert-butoxycarbonyl)amino)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl)acetate

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Technology Process of methyl 2-(2-((2-((4-(4-((tert-butoxycarbonyl)amino)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl)acetate

There total 9 articles about methyl 2-(2-((2-((4-(4-((tert-butoxycarbonyl)amino)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1393901-35-3
tert-butyl (1-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidin-4-yl)carbamate

: 637348-19-7
(2-ethynylphenyl)acetic acid methyl ester

: 1393901-36-4
methyl 2-(2-((2-((4-(4-((tert-butoxycarbonyl)amino)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl)acetate

Guidance literature:: With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triphenylphosphine; In N,N-dimethyl-formamide; at 120 ℃; for 0.333333h; microwave irradiation;

Reference yield:

: 1393901-35-3
tert-butyl (1-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidin-4-yl)carbamate

: 637348-19-7
(2-ethynylphenyl)acetic acid methyl ester

: 1393901-36-4
methyl 2-(2-((2-((4-(4-((tert-butoxycarbonyl)amino)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl)acetate

: C₂₂H₁₈O₄

Guidance literature:: tert-butyl (1-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidin-4-yl)carbamate; With copper(l) iodide; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; for 0.0833333h; Sonication;

(2-ethynylphenyl)acetic acid methyl ester; With trans-bis(triphenylphosphine)palladium dichloride; In N,N-dimethyl-formamide; at 120 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1393901-36-4
methyl 2-(2-((2-((4-(4-((tert-butoxycarbonyl)amino)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.25 h / 150 °C / microwave irradiation

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; N,N-dimethyl-formamide; ethanol / 18 h / 20 °C / sealed tube

3.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.67 h / 0 °C

3.2: 18 h / 0 - 20 °C

4.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / microwave irradiation

With hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; zinc(II) chloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; triphenylphosphine; In diethyl ether; ethanol; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;