tert-Butyl (1-(4-aminophenyl)piperidin-4-yl)carbamate

Base Information

Chemical Name:tert-Butyl (1-(4-aminophenyl)piperidin-4-yl)carbamate
CAS No.:392335-22-7
Molecular Formula:C16H25N3O2
Molecular Weight:291.393
Hs Code.:
European Community (EC) Number:895-857-8
Mol file:392335-22-7.mol

Synonyms:392335-22-7;tert-Butyl (1-(4-aminophenyl)piperidin-4-yl)carbamate;tert-butyl N-[1-(4-aminophenyl)piperidin-4-yl]carbamate;SCHEMBL3130708;LWNOWFDLCFGFDH-UHFFFAOYSA-N;EN300-12464978;A1-56283;tert-Butyl(1-(4-aminophenyl)piperidin-4-yl)carbamate

Suppliers and Price of tert-Butyl (1-(4-aminophenyl)piperidin-4-yl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of tert-Butyl (1-(4-aminophenyl)piperidin-4-yl)carbamate

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:291.19467705
Heavy Atom Count:21
Complexity:338

Purity/Quality:: 95-99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC1CCN(CC1)C2=CC=C(C=C2)N

Technology Process of tert-Butyl (1-(4-aminophenyl)piperidin-4-yl)carbamate

There total 5 articles about tert-Butyl (1-(4-aminophenyl)piperidin-4-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 392335-21-6
tert-butyl N-[1-(4-nitrophenyl)piperidin-4-yl]carbamate

: 392335-22-7
[1-(4-aminophenyl)piperidin-4-yl]carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; ethyl acetate; N,N-dimethyl-formamide; at 20 ℃; for 18h; sealed tube;

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 392335-22-7
[1-(4-aminophenyl)piperidin-4-yl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.25 h / 150 °C / microwave irradiation

2: hydrogen / palladium 10% on activated carbon / ethyl acetate; N,N-dimethyl-formamide; ethanol / 18 h / 20 °C / sealed tube

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In ethanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 100-00-5
4-chlorobenzonitrile

: 392335-22-7
[1-(4-aminophenyl)piperidin-4-yl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 100 °C

2: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 20 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.6b00902