tert-butyl 3-((naphthalen-1-ylmethyl)(4-((2-nitro-N-(pyridin-2-ylmethyl)phenylsulfonamido)methyl)benzyl)amino)propylcarbamate

Base Information

Chemical Name:tert-butyl 3-((naphthalen-1-ylmethyl)(4-((2-nitro-N-(pyridin-2-ylmethyl)phenylsulfonamido)methyl)benzyl)amino)propylcarbamate
CAS No.:1439361-98-4
Molecular Formula:C₃₉H₄₃N₅O₆S
Molecular Weight:709.866
Hs Code.:

Synonyms:tert-butyl 3-((naphthalen-1-ylmethyl)(4-((2-nitro-N-(pyridin-2-ylmethyl)phenylsulfonamido)methyl)benzyl)amino)propylcarbamate

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Chemical Property of tert-butyl 3-((naphthalen-1-ylmethyl)(4-((2-nitro-N-(pyridin-2-ylmethyl)phenylsulfonamido)methyl)benzyl)amino)propylcarbamate

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Technology Process of tert-butyl 3-((naphthalen-1-ylmethyl)(4-((2-nitro-N-(pyridin-2-ylmethyl)phenylsulfonamido)methyl)benzyl)amino)propylcarbamate

There total 13 articles about tert-butyl 3-((naphthalen-1-ylmethyl)(4-((2-nitro-N-(pyridin-2-ylmethyl)phenylsulfonamido)methyl)benzyl)amino)propylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 586-98-1
2-Hydroxymethylpyridine

: 1439361-97-3
tert-butyl 3-((naphthalen-1-ylmethyl)(4-((2-nitrophenylsulfonamido)methyl)benzyl)amino)propylcarbamate

: 1439361-98-4
tert-butyl 3-((naphthalen-1-ylmethyl)(4-((2-nitro-N-(pyridin-2-ylmethyl)phenylsulfonamido)methyl)benzyl)amino)propylcarbamate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 0 - 20 ℃;
DOI:10.1002/cmdc.201200390

Reference yield:

: 1439361-95-1
tert-butyl 3-(N-(naphthalen-1-ylmethyl)-2-nitrophenylsulfonamido)propylcarbamate

: 1439361-98-4
tert-butyl 3-((naphthalen-1-ylmethyl)(4-((2-nitro-N-(pyridin-2-ylmethyl)phenylsulfonamido)methyl)benzyl)amino)propylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 2 h / 20 °C

2: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 0 - 20 °C

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 0 - 20 °C

With sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; thiophenol; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; 3: |Mitsunobu Displacement;
DOI:10.1002/cmdc.201200390

Reference yield:

: 244289-94-9
N-((o-Nitrophenyl)sulfenyl)-4-(aminomethyl)benzoic acid

: 1439361-98-4
tert-butyl 3-((naphthalen-1-ylmethyl)(4-((2-nitro-N-(pyridin-2-ylmethyl)phenylsulfonamido)methyl)benzyl)amino)propylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0 - 20 °C

2: diisobutylaluminium hydride / dichloromethane; hexane / 1 h / -78 °C / Inert atmosphere

3: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 0 - 20 °C

4: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 0 - 20 °C

With sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; hexane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; 4: |Mitsunobu Displacement;
DOI:10.1002/cmdc.201200390