FMOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID

Base Information

• Chemical Name: FMOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID
• CAS No.: 884880-39-1
• Molecular Formula: C20H21NO5
• Molecular Weight: 355.39
• Mol file: 884880-39-1.mol

Synonyms:(R)-2-(tert-butoxycarbonylamino)-3-hydroxy-3-methylbutanoic acid;(2R)-2-[(tert-butoxycarbonyl)amino]-3-hydroxy-3-methylbutanoic acid;Fmoc-D-OHVal;(R)-N-Boc-2-amino-3-hydroxy-3-methylbutanoic acid;

Chemical Property of FMOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID

Chemical Property:

• PSA: 99.35000
• LogP: 2.95360
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Fmoc-(R)-2-amino-3-hydroxy-3-methylbutanoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID

There total 2 articles about FMOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) + (R)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid (288159-40-0,105504-72-1) → Fmoc-D-OHVal (884880-39-1)

Guidance literature:

(R)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid; With trifluoroacetic acid; In dichloromethane;

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide; With sodium hydrogencarbonate; In water; acetone;

Reference yield:

(R)-(-)-β-hydroxyvaline (2280-48-0,5174-30-1) + (fluorenylmethoxy)carbonyl chloride (28920-43-6) → Fmoc-D-OHVal (884880-39-1)

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane; water;

DOI:10.1038/nchem.554

Reference yield: 87.0%

Fmoc-D-OHVal (884880-39-1) + benzyl bromide (100-39-0) → C27H27NO5

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 42h; Inert atmosphere;

DOI:10.1021/jacs.8b06755

upstream raw materials:

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

(R)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid

(R)-(-)-β-hydroxyvaline

(fluorenylmethoxy)carbonyl chloride

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 884880-39-1 FMOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID

Send

Send

Metric Ton KG G Pound L ML

Send

Send