11-phenyl-2,3-dihydro-1H-5a,11a-(epiminomethano)indeno[2,1-f]indolizine-5,12(6H)-dione

Base Information

Chemical Name:11-phenyl-2,3-dihydro-1H-5a,11a-(epiminomethano)indeno[2,1-f]indolizine-5,12(6H)-dione
CAS No.:1549876-48-3
Molecular Formula:C₂₂H₁₈N₂O₂
Molecular Weight:342.397
Hs Code.:

Synonyms:11-phenyl-2,3-dihydro-1H-5a,11a-(epiminomethano)indeno[2,1-f]indolizine-5,12(6H)-dione

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Chemical Property of 11-phenyl-2,3-dihydro-1H-5a,11a-(epiminomethano)indeno[2,1-f]indolizine-5,12(6H)-dione

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Technology Process of 11-phenyl-2,3-dihydro-1H-5a,11a-(epiminomethano)indeno[2,1-f]indolizine-5,12(6H)-dione

There total 5 articles about 11-phenyl-2,3-dihydro-1H-5a,11a-(epiminomethano)indeno[2,1-f]indolizine-5,12(6H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1549876-37-0
12-methoxy-11-phenyl-2,3-dihydro-1H-5a,11a-(azenometheno)indeno[2,1-f]indolizin-5(6H)-one

: 1549876-48-3
11-phenyl-2,3-dihydro-1H-5a,11a-(epiminomethano)indeno[2,1-f]indolizine-5,12(6H)-dione

Guidance literature:: With acetic acid; potassium iodide; at 100 ℃; Inert atmosphere;
DOI:10.1021/ol403632t

Reference yield:

: 38074-72-5
(S)-1-(2-chloroacetyl)pyrrolidine-2-carboxylic acid methyl ester

: 1549876-48-3
11-phenyl-2,3-dihydro-1H-5a,11a-(epiminomethano)indeno[2,1-f]indolizine-5,12(6H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium azide / butanone / 72 h / 80 °C / Inert atmosphere

2.1: triphenylphosphine / toluene / 19 h / 20 - 90 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / toluene; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: 0.25 h / -78 °C / Inert atmosphere

4.1: acetic acid; potassium iodide / 100 °C / Inert atmosphere

With sodium azide; acetic acid; triphenylphosphine; potassium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; toluene; butanone;
DOI:10.1021/ol403632t

Reference yield:

: 2577-48-2
methyl (2S)-pyrrolidine carboxylate

: 1549876-48-3
11-phenyl-2,3-dihydro-1H-5a,11a-(epiminomethano)indeno[2,1-f]indolizine-5,12(6H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere

2.1: sodium azide / butanone / 72 h / 80 °C / Inert atmosphere

3.1: triphenylphosphine / toluene / 19 h / 20 - 90 °C / Inert atmosphere

4.1: lithium hexamethyldisilazane / toluene; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

4.2: 0.25 h / -78 °C / Inert atmosphere

5.1: acetic acid; potassium iodide / 100 °C / Inert atmosphere

With sodium azide; acetic acid; triethylamine; triphenylphosphine; potassium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; toluene; butanone;
DOI:10.1021/ol403632t