12-methoxy-11-phenyl-2,3-dihydro-1H-5a,11a-(azenometheno)indeno[2,1-f]indolizin-5(6H)-one

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Chemical Name:12-methoxy-11-phenyl-2,3-dihydro-1H-5a,11a-(azenometheno)indeno[2,1-f]indolizin-5(6H)-one
CAS No.:1549876-37-0
Molecular Formula:C₂₃H₂₀N₂O₂
Molecular Weight:356.424
Hs Code.:

Synonyms:12-methoxy-11-phenyl-2,3-dihydro-1H-5a,11a-(azenometheno)indeno[2,1-f]indolizin-5(6H)-one

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Chemical Property of 12-methoxy-11-phenyl-2,3-dihydro-1H-5a,11a-(azenometheno)indeno[2,1-f]indolizin-5(6H)-one

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Technology Process of 12-methoxy-11-phenyl-2,3-dihydro-1H-5a,11a-(azenometheno)indeno[2,1-f]indolizin-5(6H)-one

There total 4 articles about 12-methoxy-11-phenyl-2,3-dihydro-1H-5a,11a-(azenometheno)indeno[2,1-f]indolizin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 916504-58-0
(8aS)-6,7,8,8a-tetrahydro-1-methoxypyrrolo[1,2-a]pyrazin-4(3H)-one

: 59046-72-9
o-(phenylethynyl)benzaldehyde

: 1549876-37-0
12-methoxy-11-phenyl-2,3-dihydro-1H-5a,11a-(azenometheno)indeno[2,1-f]indolizin-5(6H)-one

Guidance literature:: (8aS)-6,7,8,8a-tetrahydro-1-methoxypyrrolo[1,2-a]pyrazin-4(3H)-one; With lithium hexamethyldisilazane; In tetrahydrofuran; toluene; at -78 ℃; for 0.5h; Inert atmosphere;

o-(phenylethynyl)benzaldehyde; In tetrahydrofuran; toluene; at -78 ℃; for 0.25h; Further stages; Inert atmosphere;
DOI:10.1021/ol403632t

Reference yield:

: 38074-72-5
(S)-1-(2-chloroacetyl)pyrrolidine-2-carboxylic acid methyl ester

: 1549876-37-0
12-methoxy-11-phenyl-2,3-dihydro-1H-5a,11a-(azenometheno)indeno[2,1-f]indolizin-5(6H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium azide / butanone / 72 h / 80 °C / Inert atmosphere

2.1: triphenylphosphine / toluene / 19 h / 20 - 90 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / toluene; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: 0.25 h / -78 °C / Inert atmosphere

With sodium azide; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; toluene; butanone;
DOI:10.1021/ol403632t

Reference yield:

: 914468-21-6
N-(azidoacetyl)-L-proline methyl ester

: 1549876-37-0
12-methoxy-11-phenyl-2,3-dihydro-1H-5a,11a-(azenometheno)indeno[2,1-f]indolizin-5(6H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine / toluene / 19 h / 20 - 90 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / toluene; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 0.25 h / -78 °C / Inert atmosphere

With triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; toluene;
DOI:10.1021/ol403632t