1-(CHLOROACETYL)-L-PROLINE METHYL ESTER

Base Information

Chemical Name:1-(CHLOROACETYL)-L-PROLINE METHYL ESTER
CAS No.:38074-72-5
Molecular Formula:C₈H₁₂ClNO₃
Molecular Weight:205.641
Hs Code.:
Mol file:38074-72-5.mol

Synonyms:(S)-1-(2-chloroacetyl)pyrrolidine-2-carboxylic acid methyl ester

Suppliers and Price of 1-(CHLOROACETYL)-L-PROLINE METHYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 16 raw suppliers

Chemical Property of 1-(CHLOROACETYL)-L-PROLINE METHYL ESTER

Chemical Property:

Purity/Quality:: 95%+HPLC ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses N-Chloroacetyl-L-proline Methyl Ester is an impurity of Vildagliptin (V305000), a class of oral anti-hyperglycemic agents that inhibit dipeptidyl peptidase 4 (DPP-4), which can act as a serine exopeptidase. Aside from their use in type 2 diabetes, gliptins have positive cardiovascular and anti-inflammtatory effects. Antidiabetic.

Technology Process of 1-(CHLOROACETYL)-L-PROLINE METHYL ESTER

There total 7 articles about 1-(CHLOROACETYL)-L-PROLINE METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 2577-48-2
methyl (2S)-pyrrolidine carboxylate

: 79-04-9
chloroacetyl chloride

: 38074-72-5
(S)-1-(2-chloroacetyl)pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: With sodium hydrogencarbonate; at 0 ℃; for 1.25h;

Reference yield: 89.0%

: 2133-40-6
L-proline methyl ester monohydrochloride

: 79-11-8
chloroacetic acid

: 38074-72-5
(S)-1-(2-chloroacetyl)pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1021/ol061657d

Reference yield: 80.0%

: 67-56-1
methanol

: 79-04-9
chloroacetyl chloride

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 38074-72-5
(S)-1-(2-chloroacetyl)pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: methanol; L-proline; With thionyl chloride; at 10 - 30 ℃; for 2h; Reflux; Inert atmosphere;

chloroacetyl chloride; With potassium hydrogencarbonate; at 10 - 15 ℃; for 1h;