Technology Process of (11aS)-3-(9-benzyloxy-8-methyl-5,11-dioxo-5,10,11,11a-tetrahydro-3H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-2-yl)acrylic acid methyl ester
There total 13 articles about (11aS)-3-(9-benzyloxy-8-methyl-5,11-dioxo-5,10,11,11a-tetrahydro-3H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-2-yl)acrylic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
[1,3-Mes2-(N2C3H5)]Cl2Ru=CH(2-isopropoxy-3-Ph-C6H3);
In
dichloromethane;
for 17h;
Heating;
DOI:10.1016/j.tet.2004.07.040
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 93 mg / Et3N / CH2Cl2 / 12 h / 0 °C
2: Zn; AcOH / CH2Cl2 / 0.33 h / 20 °C
3: 451 mg / aq. HCl / tetrahydrofuran / 24 h / 20 °C
4: 91 percent / [1,3-Mes2-(N2C3H5)]Cl2(PCy3)Ru=CHPh / CH2Cl2 / 12 h / Heating
5: K2CO3 / methanol / 9 h / 0 °C
6: MnO2 / CH2Cl2 / 72 h / 20 °C
7: aq. NaClO2; KH2PO4; 2-methyl-2-butene / 2-methyl-propan-2-ol / 3 h / 20 °C
8: 11 mg / SOCl2 / 18 h / 20 °C
With
hydrogenchloride; manganese(IV) oxide; sodium chlorite; potassium dihydrogenphosphate; thionyl chloride; 2-methyl-but-2-ene; [1,3-Mes2-(N2C3H5)]Cl2(PCy3)Ru=CHPh; potassium carbonate; acetic acid; triethylamine; zinc;
In
tetrahydrofuran; methanol; dichloromethane; tert-butyl alcohol;
DOI:10.1016/j.tet.2004.07.040
- Guidance literature:
-
Multi-step reaction with 13 steps
1: 100 percent / aq. KHCO3 / ethyl acetate / 14 h / 0 °C
2: 100 percent / aq. NaIO4 / methanol / 4 h / 0 °C
3: 37 percent / xylene / 60 h / 140 °C
4: 76 percent / (PCy3)2Cl2Ru=CHPh / CH2Cl2 / 24 h / 20 °C
5: TMSCl; NaI / acetonitrile / 10 h / 20 °C
6: 93 mg / Et3N / CH2Cl2 / 12 h / 0 °C
7: Zn; AcOH / CH2Cl2 / 0.33 h / 20 °C
8: 451 mg / aq. HCl / tetrahydrofuran / 24 h / 20 °C
9: 91 percent / [1,3-Mes2-(N2C3H5)]Cl2(PCy3)Ru=CHPh / CH2Cl2 / 12 h / Heating
10: K2CO3 / methanol / 9 h / 0 °C
11: MnO2 / CH2Cl2 / 72 h / 20 °C
12: aq. NaClO2; KH2PO4; 2-methyl-2-butene / 2-methyl-propan-2-ol / 3 h / 20 °C
13: 11 mg / SOCl2 / 18 h / 20 °C
With
hydrogenchloride; manganese(IV) oxide; sodium chlorite; sodium periodate; potassium dihydrogenphosphate; Grubbs catalyst first generation; chloro-trimethyl-silane; thionyl chloride; 2-methyl-but-2-ene; [1,3-Mes2-(N2C3H5)]Cl2(PCy3)Ru=CHPh; potassium carbonate; potassium hydrogencarbonate; acetic acid; triethylamine; sodium iodide; zinc;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate; acetonitrile; xylene; tert-butyl alcohol;
DOI:10.1016/j.tet.2004.07.040
