(4-chloro-2-methoxy-3-(4-(methylsulfonyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanone

Base Information

Chemical Name:(4-chloro-2-methoxy-3-(4-(methylsulfonyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanone
CAS No.:1599529-31-3
Molecular Formula:C₂₃H₂₀ClN₃O₄S
Molecular Weight:469.948
Hs Code.:

Synonyms:(4-chloro-2-methoxy-3-(4-(methylsulfonyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanone

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Chemical Property of (4-chloro-2-methoxy-3-(4-(methylsulfonyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanone

Chemical Property:

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Technology Process of (4-chloro-2-methoxy-3-(4-(methylsulfonyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanone

There total 8 articles about (4-chloro-2-methoxy-3-(4-(methylsulfonyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5398-77-6
para-methanesulfonylbenzaldehyde

: 1599529-31-3
(4-chloro-2-methoxy-3-(4-(methylsulfonyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: L-proline / ethanol / 1 h / 20 °C

1.2: 3 h

2.1: sodium hydroxide; water / 0.33 h / 120 °C / Microwave irradiation

3.1: trichlorophosphate / 4 h / 105 °C

4.1: toluene / 6 h / 105 °C / Sealed tube

With water; L-proline; sodium hydroxide; trichlorophosphate; In ethanol; toluene;

Reference yield:

: 1599529-30-2
(2,4-dichloro-3-(4-(methylsulfonyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanone

: 124-41-4
sodium methylate

: 1599529-31-3
(4-chloro-2-methoxy-3-(4-(methylsulfonyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanone

Guidance literature:: In toluene; at 105 ℃; for 12h; Sealed tube;

Reference yield:

: 1599529-10-8
(1-methyl-1H-imidazol-5-yl)(4-nitrophenyl)methanone

: 1599529-31-3
(4-chloro-2-methoxy-3-(4-(methylsulfonyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: tin(II) chloride dihdyrate / ethanol / 1 h / Reflux

2: trichlorophosphate / 4 h / 105 °C

3: toluene / 12 h / 105 °C / Sealed tube

With tin(II) chloride dihdyrate; trichlorophosphate; In ethanol; toluene;