3-allyl-5-methoxy-2-methyl-1-[(4-methylphenyl)sulfonyl]-1H-indole

Base Information

Chemical Name:3-allyl-5-methoxy-2-methyl-1-[(4-methylphenyl)sulfonyl]-1H-indole
CAS No.:1429887-51-3
Molecular Formula:C₂₀H₂₁NO₃S
Molecular Weight:355.458
Hs Code.:

Synonyms:3-allyl-5-methoxy-2-methyl-1-[(4-methylphenyl)sulfonyl]-1H-indole

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Chemical Property of 3-allyl-5-methoxy-2-methyl-1-[(4-methylphenyl)sulfonyl]-1H-indole

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Technology Process of 3-allyl-5-methoxy-2-methyl-1-[(4-methylphenyl)sulfonyl]-1H-indole

There total 1 articles about 3-allyl-5-methoxy-2-methyl-1-[(4-methylphenyl)sulfonyl]-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1314595-90-8
N-(2-iodo-4-methoxylphenyl)-4-methylbenzenesulfonamide

: 69643-52-3
hex-5-en-2-ynyl bromide

: 1429887-51-3
3-allyl-5-methoxy-2-methyl-1-[(4-methylphenyl)sulfonyl]-1H-indole

Guidance literature:: hex-5-en-2-ynyl bromide; With indium; sodium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h; Schlenk technique; Inert atmosphere;

N-(2-iodo-4-methoxylphenyl)-4-methylbenzenesulfonamide; With trifuran-2-yl-phosphane; palladium diacetate; In N,N-dimethyl-formamide; at 100 ℃; for 12h; Schlenk technique; Inert atmosphere;
DOI:10.1021/ol401115a

Reference yield:

: 1429887-51-3
3-allyl-5-methoxy-2-methyl-1-[(4-methylphenyl)sulfonyl]-1H-indole

: 53-86-1
[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / ethanol / 12 h / 80 °C / Schlenk technique; Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 0.33 h / 0 °C / Schlenk technique; Inert atmosphere

2.2: 10 h / 0 - 20 °C / Schlenk technique; Inert atmosphere

3.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / water; acetone / 12 h / 20 °C / Schlenk technique

4.1: sodium periodate / water; methanol / 8 h / 20 °C / Schlenk technique

5.1: sodium dihydrogenphosphate; sodium chlorite / water; tetrahydrofuran; tert-butyl alcohol / 0.5 h / 20 °C / Schlenk technique

With sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; potassium tert-butylate; 4-methylmorpholine N-oxide; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; water; acetone; tert-butyl alcohol;
DOI:10.1021/ol401115a

Reference yield:

: 1429887-51-3
3-allyl-5-methoxy-2-methyl-1-[(4-methylphenyl)sulfonyl]-1H-indole

: 24438-50-4
3-allyl-5-methoxy-2-methyl-1-(4-chlorobenzoyl)indole

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / ethanol / 12 h / 80 °C / Schlenk technique; Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 0.33 h / 0 °C / Schlenk technique; Inert atmosphere

2.2: 10 h / 0 - 20 °C / Schlenk technique; Inert atmosphere

With potassium tert-butylate; potassium hydroxide; In tetrahydrofuran; ethanol;
DOI:10.1021/ol401115a