3-allyl-5-methoxy-2-methyl-1-(4-chlorobenzoyl)indole

Base Information

• Chemical Name: 3-allyl-5-methoxy-2-methyl-1-(4-chlorobenzoyl)indole
• CAS No.: 24438-50-4
• Molecular Formula: C₂₀H₁₈ClNO₂
• Molecular Weight: 339.821
• Mol file: 24438-50-4.mol

Synonyms:3-allyl-5-methoxy-2-methyl-1-(4-chlorobenzoyl)indole

Chemical Property of 3-allyl-5-methoxy-2-methyl-1-(4-chlorobenzoyl)indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-allyl-5-methoxy-2-methyl-1-(4-chlorobenzoyl)indole

There total 4 articles about 3-allyl-5-methoxy-2-methyl-1-(4-chlorobenzoyl)indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

zhucan-7-13 (1429887-67-1) + 4-chloro-benzoyl chloride (122-01-0) → 3-allyl-5-methoxy-2-methyl-1-(4-chlorobenzoyl)indole (24438-50-4)

Guidance literature:

zhucan-7-13; With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 0.333333h; Schlenk technique; Inert atmosphere;

4-chloro-benzoyl chloride; In tetrahydrofuran; at 0 - 20 ℃; for 10h; Schlenk technique; Inert atmosphere;

DOI:10.1021/ol401115a

Reference yield:

N-(2-iodo-4-methoxylphenyl)-4-methylbenzenesulfonamide (1314595-90-8) → 3-allyl-5-methoxy-2-methyl-1-(4-chlorobenzoyl)indole (24438-50-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium iodide; indium / N,N-dimethyl-formamide / 0.25 h / 20 °C / Schlenk technique; Inert atmosphere

1.2: 12 h / 100 °C / Schlenk technique; Inert atmosphere

2.1: potassium hydroxide / ethanol / 12 h / 80 °C / Schlenk technique; Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 0.33 h / 0 °C / Schlenk technique; Inert atmosphere

3.2: 10 h / 0 - 20 °C / Schlenk technique; Inert atmosphere

With indium; potassium tert-butylate; sodium iodide; potassium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/ol401115a

Reference yield:

hex-5-en-2-ynyl bromide (69643-52-3) → 3-allyl-5-methoxy-2-methyl-1-(4-chlorobenzoyl)indole (24438-50-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium iodide; indium / N,N-dimethyl-formamide / 0.25 h / 20 °C / Schlenk technique; Inert atmosphere

1.2: 12 h / 100 °C / Schlenk technique; Inert atmosphere

2.1: potassium hydroxide / ethanol / 12 h / 80 °C / Schlenk technique; Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 0.33 h / 0 °C / Schlenk technique; Inert atmosphere

3.2: 10 h / 0 - 20 °C / Schlenk technique; Inert atmosphere

With indium; potassium tert-butylate; sodium iodide; potassium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/ol401115a

upstream raw materials:

3-allyl-5-methoxy-2-methyl-1-[(4-methylphenyl)sulfonyl]-1H-indole

zhucan-7-13

4-chloro-benzoyl chloride

N-(2-iodo-4-methoxylphenyl)-4-methylbenzenesulfonamide

Downstream raw materials:

zhucan-7-15

<1-(4-chlorobenzoyl)-2-methyl-5-methoxyindol-3-yl>acetaldehyde

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Refernces