7-O-(triethylsilyl)baccatin III 13-O-[(Z)-3-amino-N-benzoyl-3-(4-pyridyl)acrylate]

Base Information

Chemical Name:7-O-(triethylsilyl)baccatin III 13-O-[(Z)-3-amino-N-benzoyl-3-(4-pyridyl)acrylate]
CAS No.:175918-02-2
Molecular Formula:C₅₂H₆₂N₂O₁₃Si
Molecular Weight:951.155
Hs Code.:

Synonyms:7-O-(triethylsilyl)baccatin III 13-O-[(Z)-3-amino-N-benzoyl-3-(4-pyridyl)acrylate]

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Chemical Property of 7-O-(triethylsilyl)baccatin III 13-O-[(Z)-3-amino-N-benzoyl-3-(4-pyridyl)acrylate]

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Technology Process of 7-O-(triethylsilyl)baccatin III 13-O-[(Z)-3-amino-N-benzoyl-3-(4-pyridyl)acrylate]

There total 5 articles about 7-O-(triethylsilyl)baccatin III 13-O-[(Z)-3-amino-N-benzoyl-3-(4-pyridyl)acrylate] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 115437-21-3
7-(triethylsilyl)baccatin III

: 158271-92-2
(3R,4S)-1-benzoyl-3-<(tert-butyldimethylsilyl)oxy>-4-(4-pyridyl)-2-azetidinone

: 175918-02-2
7-O-(triethylsilyl)baccatin III 13-O-[(Z)-3-amino-N-benzoyl-3-(4-pyridyl)acrylate]

: 158307-74-5
2-O-(tert-butyldimethylsilyl)-3'-dephenyl-3'-(4-pyridyl)-7-O-(triethylsilyl)paclitaxel

Guidance literature:: With sodium hydride; In tetrahydrofuran; 1.) 0 deg C, 0.5 h, 2.) 30 deg C, 3 h;
DOI:10.1021/jo951961c

Reference yield:

: 994-30-9
triethylsilyl chloride

: 175918-02-2
7-O-(triethylsilyl)baccatin III 13-O-[(Z)-3-amino-N-benzoyl-3-(4-pyridyl)acrylate]

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / pyridine / 12 h / Ambient temperature

2: 20 percent / NaH / tetrahydrofuran / 1.) 0 deg C, 0.5 h, 2.) 30 deg C, 3 h

With pyridine; sodium hydride; In tetrahydrofuran;
DOI:10.1021/jo951961c

Reference yield:

: 98-88-4
benzoyl chloride

: 175918-02-2
7-O-(triethylsilyl)baccatin III 13-O-[(Z)-3-amino-N-benzoyl-3-(4-pyridyl)acrylate]

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / Et₃N, DMAP / CH₂Cl₂ / 0.25 h / 0 °C

2: 20 percent / NaH / tetrahydrofuran / 1.) 0 deg C, 0.5 h, 2.) 30 deg C, 3 h

With dmap; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo951961c