(R)-2-methyl-propane-2-sulfinic acid {(R)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-propyl}-amide

Base Information

Chemical Name:(R)-2-methyl-propane-2-sulfinic acid {(R)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-propyl}-amide
CAS No.:1434822-15-7
Molecular Formula:C₁₉H₃₃ClFNO₂SSi
Molecular Weight:422.079
Hs Code.:

Synonyms:(R)-2-methyl-propane-2-sulfinic acid {(R)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-propyl}-amide

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Chemical Property of (R)-2-methyl-propane-2-sulfinic acid {(R)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-propyl}-amide

Chemical Property:

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Technology Process of (R)-2-methyl-propane-2-sulfinic acid {(R)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-propyl}-amide

There total 10 articles about (R)-2-methyl-propane-2-sulfinic acid {(R)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-propyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1434722-74-3
(R)-2-methyl-propane-2-sulfinic acid (E)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-methylideneamide

: 925-90-6
ethylmagnesium bromide

: 1434822-15-7
(R)-2-methyl-propane-2-sulfinic acid {(R)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-propyl}-amide

: 1434822-21-5
C₁₉H₃₃ClFNO₂SSi

Guidance literature:: In tetrahydrofuran; diethyl ether; at -78 ℃; for 3h; Inert atmosphere;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1434822-15-7
(R)-2-methyl-propane-2-sulfinic acid {(R)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-propyl}-amide

: 1434822-21-5
C₁₉H₃₃ClFNO₂SSi

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

2: titanium(IV) tetraethanolate / dichloromethane / 20 °C / Inert atmosphere

3: tetrahydrofuran; diethyl ether / 3 h / -78 °C / Inert atmosphere

With 1H-imidazole; titanium(IV) tetraethanolate; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1434722-68-5
4-chloro-2-fluoro-3-hydroxybenzaldehyde

: 1434822-15-7
(R)-2-methyl-propane-2-sulfinic acid {(R)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-propyl}-amide

: 1434822-21-5
C₁₉H₃₃ClFNO₂SSi

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

2: titanium(IV) tetraethanolate / dichloromethane / 20 °C / Inert atmosphere

3: tetrahydrofuran; diethyl ether / 3 h / -78 °C / Inert atmosphere

With 1H-imidazole; titanium(IV) tetraethanolate; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;