3-Bromo-2-hydroxy-5-methylpyridine

Base Information

• Chemical Name: 3-Bromo-2-hydroxy-5-methylpyridine
• CAS No.: 17282-02-9
• Molecular Formula: C6H6BrNO
• Molecular Weight: 188.02
• Hs Code.: 29333990
• European Community (EC) Number: 623-885-0
• DSSTox Substance ID: DTXSID00395569
• Nikkaji Number: J3.151.646C
• Wikidata: Q72456908
• Mol file: 17282-02-9.mol

Synonyms:17282-02-9;3-Bromo-2-hydroxy-5-methylpyridine;3-bromo-5-methylpyridin-2-ol;3-Bromo-5-methylpyridin-2(1H)-one;3-bromo-5-methyl-1H-pyridin-2-one;3-BROMO-5-METHYL-2(1H)-PYRIDINONE;3-Bromo-2-hydroxy-5-picoline;3-Bromo-5-methyl-pyridin-2-ol;MFCD03791312;2(1H)-Pyridinone, 3-bromo-5-methyl-;3-Bromo-5-methyl-2-pyridone;3-Bromo-5-methyl-2-pyridinol;SCHEMBL1542620;DTXSID00395569;KHBRMXVUQOVORD-UHFFFAOYSA-N;AMY31245;BBL102276;STL556075;AKOS015834420;AKOS015891790;AB16221;AC-5170;CS-W003118;FS-3429;SY019176;3-Bromo-2-hydroxy-5-methylpyridine, 97%;A3807;B3350;FT-0656753;EN300-179948;J-512040

Chemical Property of 3-Bromo-2-hydroxy-5-methylpyridine

Chemical Property:

• Vapor Pressure: 0.000253mmHg at 25°C
• Melting Point: 78-82 °C(lit.)
• Refractive Index: 1.573
• Boiling Point: 324 °C at 760 mmHg
• PKA: 10.95±0.10(Predicted)
• Flash Point: 149.7 °C
• PSA: 33.12000
• Density: 1.622 g/cm³
• LogP: 1.85810
• Storage Temp.: Keep Cold
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 186.96328
• Heavy Atom Count: 9
• Complexity: 205

Purity/Quality:

99% ^*data from raw suppliers

3-Bromo-5-methyl-2(1H)-pyridinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xn,Xi
• Statements: 22-37/38-41-36/37/38
• Safety Statements: 26-36/37/39-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CNC(=O)C(=C1)Br

Technology Process of 3-Bromo-2-hydroxy-5-methylpyridine

There total 4 articles about 3-Bromo-2-hydroxy-5-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5-methyl-pyridin-2-ol (1003-68-5,91914-06-6) → 2-hydroxy-3-bromo-5-methylpyridine (17282-02-9)

Guidance literature:

With bromine; In carbon disulfide; at 20 ℃; for 2h;

Reference yield: 59.0%

5-methyl-2-pyridone (1003-68-5) → 3-bromo-5-methylpyridine-2-pyridone (17282-02-9)

Guidance literature:

With bromine; In chloroform; Ambient temperature; overnight;

Reference yield:

→ 2-hydroxy-3-bromo-5-methylpyridine (17282-02-9)

Guidance literature:

2-Amino-3-brom-5-methyl-pyridin/65percentig. Hexafluorphosphorsaeure, NaNO2/W. (0grad,30 Min.; dann 50grad);

upstream raw materials:

5-methyl-pyridin-2-ol

5-methyl-2-pyridone

Downstream raw materials:

3-bromo-2-chloro-5-methyl-pyridine

C₁₉H₂₃BrN₂O₃

N-[4-[(E)-2-[3-tert-butyl-2-methoxy-5-(5-methyl-2-oxo-1H-pyridin-3-yl)phenyl]vinyl]phenyl]methanesulfonamide

2-methoxy-5-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Refernces

• 1、 -. "3-Pyridinecarboxamide derivatives as HDL-cholesterol raising agents". Page/Page column 15. . Retrieved 2008/06/13.
• 2、 Pessolano, A. A.,Witzel, B. E.,Graham, P. M.,Clark, R. L.,Jones, H.,at al.. "Novel Nucleophilic Substitution of Alkyl Bromo-2(1H)-pyridones". . p. 265 - 272. Retrieved 2007/10/02.